Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer" S$%E& S$%E& &AME'' &AME'''''' ''''''' ''''''' '''''''' '''''''' '''' (%#''''' (%#'''''''' '''
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0
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
1.
The second leading cause of death in the United States is
A. B. C. D. E. 2.
heart heart atta attack cks. s. acci accide dent ntss pneu pneum moni onia. stroke. cancer. f the follo!in follo!ing" g" the component component present present in small smallest est #uantit$ #uantit$ in the human human %od$ is is
A. B. C. D. E.
car% car%oh oh$ $drat dratee nucl nuclei eicc acid acid lipid pro protein !ater
&. An ester ester %ond %ond can %e formed formed %et!een %et!een !hich !hich of the the follo!in follo!ing g A. B. C. D. E.
'( and '( 'C( and '( 'C( and 'C( ')(2 and '( 'C( and ')(2
*. The The desi design gnat atio ion n +C( +C(2,C,C(2, in a molecule %est illustrates a-an A. B. C. D. E.
alc alcohol ald aldeh$d h$de acid acid anh anh$ $drid dridee ketone ester
.
/hic /hich h of of the the foll follo!i o!ing ng group groupss of amin amino o aci acids ds are are all all h$dr h$droph opho%i o%ic c
A. B. C. D. E.
Thre Threon oniine" ne" Aspart partiic acid acid"" Arginine nine eucine" eucin e" $sine" $sine" aline aline 3soleucine" e eucine" $ $sine aline" eucine" Alanine Arginine" ne" 3sole oleucine" aline
1
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer" 4. /hic /hich h of the the foll follo!i o!ing ng ami amino no aci acids ds is is lea least st lik likel el$ $ to to %e foun found d in an alp alpha ha,h ,hel elic ical al structure
A. B. C. D. E.
Alanine 5roline (istidine C$steine Serine
6. The The great greates estt %uff %uffer erin ing g capac capacit it$ $ at ph$s ph$sio iolo logi gical cal p( p( !oul !ould d %e pro7i pro7ide ded d %$ a pol$ pol$pep pepti tide de rich in !hich of the follo!ing amino acids A. B. C. D. E.
$sine Aspartic acid Arginine 8lutamic acid (istidine
9.
/hic /hich h of of the the foll follo! o!in ing g ami amino no aci acids ds can can %e %e pho phosp spho hor$ r$la late ted d
A. B. C. D. E.
:ethionine Tr$ptophan 5hen$lalanine $sine Serine
;.
/hic /hich h sta state teme ment nt a%ou a%outt en<$ en<$me me cata catal$ l$
A. B. C. D. E.
En<$ En<$m mes form form comp comple le=e =ess !it !ith h the their ir su%s su%str trat ates es.. En<$ En<$me mess lo!e lo!err the the act acti7 i7at atio ion n ener energ$ g$ for for chemi chemica call reac reacti tion ons. s. En<$ En<$m mes chan change ge >e# >e# for for chem chemic ical al react eactiions. ons. ?or man$ man$ en<$m en<$mes" es" the conform conformati ation on of of the the acti acti7e 7e sit sitee change changess on on %ind %inding ing su%str su%strate ates. s. 'eacti 'eactions ons occur occur at at the the acti acti7e 7e site site of the en<$mes en<$mes !here !here a precis precisee &D &D orie orienta ntatio tion n of amino amino acids is an important feature of catal$sis.
2
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
10. The e#ui e#uili li%ri %rium um consta constant nt for for the the con7er con7ersio sion n of disac disaccha charid ride" e" sucro sucrose se to to simpl simplee sugars sugars"" glucose and fructose is 100"000. /hat can $ou $ou conclude a%out the reaction Sucrose @ (2∏ glucose @ fructose A. B. C. D. E.
Beca Becaus usee the the e#ui e#uili li%r %riu ium m cons consta tant nt is high high"" it it ne7 ne7er er reac reache hess e#ui e#uili li%r %riu ium. m. Beca Becaus usee the the e#uil e#uili% i%ri rium um const constan antt is is hig high" h" it is al!a$ al!a$ss at at e#u e#uil ili% i%ri rium um 3t is a spon sponta tane neou ouss reac reacti tion on star starti ting ng !ith !ith sucr sucros ose. e. The The e#uil e#uili% i%ri rium um cons consta tant nt !ou !ould ld inc incre reas asee if the the sta start rtin ing g conce concent ntra rati tion on of glu gluco cose se !er !eree increased. At e#u e#uil ili% i%ri rium um"" the the conc concent entra rati tion on of sucr sucros osee is muc much h high higher er tha than n the the conc concent entra rati tions ons of of glucose and fructose.
11. 11. Ethanol Ethanol is con7er con7erted ted to acet acetald aldeh$ eh$de de %$ alcohol alcohol deh$drog deh$drogenas enase. e. The rate rate of format formation ion of acetaldeh$de increases as $ou increase the concentration concentration of alcohol. E7entuall$" the rate of reaction reaches a ma=imum !here further increases in the concentration of alcohol ha7e no effect. /h$ A. B. C. D. E.
All All the the alco alcoho holl deh$ deh$dr drog ogena enase se mol molecu ecule less are are %oun %ound d to alcoh alcohol ol mol molec ecule ules. s. At high high conc concen entr trat atio ion n of alco alcohol hol"" the act acti7 i7at atio ion n energ energ$ $ of the the react reactio ion n incre increas ases es.. At hig high h conce concent ntra rati tion on of alc alcoh ohol ol"" the the acti7 acti7at atio ion n energ energ$ $ of the the rea react ctio ion n decre decreas ases es.. At high high conce concentr ntrati ation on of of alco alcohol hol"" the the change change in in free free energ$ energ$ of the reacti reaction on decr decreas eases. es. At hig high h alco alcoho holl conc concen entr trat atio ion" n" the the en<$ en<$me me is is no long longer er spe speci cifi ficc for for alco alcohol hol..
12. 12.
/hic /hich h of the the foll follo!i o!ing ng sta statem tement entss a%out a%out reac reacti tion on rat ratee is not true
A. B. C. D. E.
'eacti 'eaction on rate rate is the speed speed at !hich !hich the reacti reaction on proc proceeds eeds to!ard to!ardss e#ui e#uili% li%riu rium. m. 'eac 'eacti tion on rate rate is is go7e go7ern rned ed %$ the the ener energ$ g$ %ar %arri rier er %et %et!e !een en rea react ctan ants ts and and prod product ucts. s. 'eac 'eacti tion on rate ratess are are not not sens sensit iti7 i7ee to to tem tempe pera ratu ture re.. En<$ En<$m mes can can acce accellerat eratee the the rate ate of of rea react ctio ion. n. 'ate 'ate of of for! for!ar ard d reac reacti tion on is is e#ua e#uall to the the rat ratee of re7 re7er erse se rea react ctio ion n at e#u e#uil ili% i%ri rium um
1&. All of the follo!ing statements a%out the :ichaelis constant >m are correct EX*E !hich one A. B. C. D. E.
>m is e#ua e#uall to to one one half half of the the ma= ma=im imum um 7elo 7eloci cit$ t$.. >m can can %e %e calc calcul ulat ated ed fro from m the the inte inters rsec ecti tion on of ine ine!ea !ea7e 7err + Burk Burkee plot plot !it !ith h the the horim >m is is gener generall all$ $ assoc associat iated ed !it !ith h a high high aff affini init$ t$ of of an an en<$ en<$me me for for its its su%strate. >m ma$ %e defi defined ned as the concent concentrat ration ion of the su%str su%strate ate"" !hich !hich gi7es gi7es half,m half,ma=i a=imal mal 7elocit$. >m is not not aff affec ecte ted d %$ %$ non non,c ,com ompe peti titi ti7e 7e inhi inhi%i %ito tors rs..
&
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
1*.
A drug !hich acts as a non,competiti7e inhi%itor
A. B. C. D. E.
incr increa ease sess the the stea stead$ d$ sta state te con conce cent ntra rati tion on of of ES ES comp comple le=. =. has has a stru struct ctur uree sim simil ilar ar to a su% su%sstrat trate. e. acts acts %$ dec decre reas asin ing g acti acti7e 7e en< en<$m $mee in the the reac reacti tion on mi= mi=tu ture re.. does does not not af affect ect the the ine ine!e !ea7 a7er er + Bur Burke ke plot plot.. can can %e disp displa lace ced d fro from m the the act acti7 i7ee sit sitee %$ e=ce e=cess ss su%s su%str trat ate. e.
1.
A coen<$me
A. B. C. D. E.
ma$ %e %e deri7ed fr from a 7i 7itamin. al!a al!a$ $s %ind %indss to to the the ) ter termi mina nall ami amino no aci acid d of of an an en< en<$m $me. e. is for form med from rom the the su%st u%stra ratte of of an an en< en<$ $me. ser7 ser7es es to decr decrea ease se the the opt optim imum um p( of an en<$ en<$me me.. is re#uired for all en<$mes.
14. 14.
A nega negatti7e all allost osteri eric mod modul ulat ator or
A. B. C. D. E.
%inds at the su%strate %inding site. can increase the rate of reaction at constant su%strate concentration. increases the affinit$ of su%strate for the acti7e site of the en<$me. is usuall$ the su%strate of the reaction. %inds at a site other than the acti7e site.
16.
The gl gl$cosi osidic %o %ond in su sucro crose
A. B. C. D. E.
in7ol7 in7ol7es es the anomeri anomericc car%on car%onss of %oth %oth the consti constitue tuent nt monosa monosaccha ccharid ridee unit unit units. units. pre7 pre7en ents ts gluc glucos osee adop adopti ting ng an conf config igur urat atio ion. n. cannot %e %e h$ h$drol$sed %$ %$ hu humans. link linkss a glu gluco cose se and and a gal galac acto tose se to to for form m a dis disac acch char arid ide. e. resu result ltss from from the the oi oini ning ng of t!o t!o gluc glucos osee mole molecul cules es and and the the li%e li%era rati tion on of a mol molecu ecule le of car%on dio=ide.
19.
'i%ose
A.
can e=ist e=ist as a ring ring form form in in !hic !hich h the the ring ring consi consists sts of four four car% car%on on atom atomss and and one one o=$g o=$gen en atom. occu occurrs in in nat natur uree pri prim mari aril$ as the form orm. is a ketose. is a heptose. can %e %e re reduced to to fo form so sor%itol.
B. C. D. E.
*
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
1;.
3ngest 3ngestion ion of fluoro fluoroace acetat tatee result resultss in the the inhi%i inhi%iti tion on of aconi aconitas tase. e. This This inhi inhi%it %ition ion !ould !ould %e %e e=pected to result in the accumulation of
A. B. C. D. E.
succinate. fumarate. citrate. AT5. isocitrate.
20.
/hich /hich of of the the foll follo!i o!ing ng is is produc produced ed in in one one turn turn of of the the cit citric ric acid acid TCA TCA c$cle c$cle
A. B. C. D. E.
thre hree mo molecules of of ca car%on dio=ide. de. three mo molecules of of )AD( one molecule of CT5 one molecule of )AD5(. t!o mo molecules of of p$ru7ate.
21.
The ci citric ac acid T TCA c$cl c$clee
A. B. C. D. E.
occurs in the c$tosol. is inhibited by high concentrations of ADP. incl includ udes es t!o t!o o=i o=ida dati ti7e 7e dec decar ar%o %o=$ =$la lati tion on rea react ctio ions ns.. dif differs fers from from gl$ gl$co col$ l$si siss in re# re#ui uiri ring ng )AD )AD as as a coe coen< n<$m $me. e. is acti acti7a 7ate ted d %$ %$ high high conc concen entr trat atio ions ns of AT5.
22.
C$tochrome c
A. B. C. D. E.
is the the mos mostt loos loosel el$ $ %ound %ound c$to c$toch chrom romee in the the ele elect ctro ron n tran transp spor ortt chai chain. n. underg undergoes oes releas releasee from from the mitoc mitochond hondria ria in order order to protec protectt cell cellss from from apopto apoptosis sis.. acce accept ptss ele elect ctro rons ns from from )AD( )AD( %ut %ut not not from from ?AD(2. D(2. is an int inter erme medi diar ar$ $ elec electr tron on car carri rier er %et! %et!ee een n comp comple le=es =es 33 and and 333 333.. is the the ulti ultima mate te donor donor of ele elect ctro rons ns to to o=$gen o=$gen in in mito mitoch chon ondr dria iall elec electr tron on trans transpor port. t.
2&.
3n the the mito mitocho chondr ndria ia of of a person person !ho is fatall fatall$ $ poiso poisoned ned %$ c$an c$anide ide"" !hich !hich of the follo!ing su%stances !ill %e found
A. B. C. D. E.
o=idi
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
2*. 2*.
The The s$nt s$nthes hesis is of of AT AT5 is is dri7 dri7en en %$ %$ prot proton on gra gradi dient entss that that are are
A. B. C. D. E.
increased %$ %$ dinitrophenol. form formed ed acro across ss the the oute outerr mito mitoch chon ondr dria iall mem%r em%ran anee prod produc uced ed at %oth %oth com comple= ple= 3 and and com comple= ple= 33 esta esta%l %lis ishe hed d at & site sitess in in the the elec electr tron on tra trans nspo port rt chai chain. n. enhan hanced %$ %$ in inhi%itors ors of of compl omplee= 3. 3.
2. 2.
=id =idat atio ion n of of 7er 7er$ $ lon long g chai chain n fat fatt$ t$ acid acidss occ occur urss in in the the
A. B. C. D. E.
l$sosomes. 8olgi apparatus. nuclei. c$tosol pero=isomes.
24. 24.
S$nt S$nthe hesi siss of fatt fatt$ $ aci acids ds occu occurs rs in the the
A. B. C. D. E.
l$sosomes. mitochondria. nuclei. c$tosol pero=isomes.
26.
The tran transpo sport rt of of the the car%on car%on chain chain of o=al o=aloac oaceta etate te acros acrosss the the inner inner mit mitocho ochondr ndrial ial mem%rane re#uires con7ersion of o=aloacetate to
A. B. C. D. A.
gl$ceraldeh$de. dih$dro=$acetone ph phosphate. aspartate or or malate. gl$cerol. triac$lgl$cerols.
29.
:itochondria
A.
are pelleted %$ lo!er centrifugal forces than are re#uired for the preparation of cell nuclei. are are the the mao maorr sit sitee for for the the en< en<$ $mes mes of of gl$ gl$co col$ l$si sis. s. e=hi% hi%it a paternal inhe nheritance. ce. are the site of of the TCA c$cle. are are the the chie chieff sit sitee in the the cell cell for for the the loc locat atio ion n of cata catala lase se act acti7 i7it it$ $.
B. C. D. E.
4
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
2;. A. B. C. D. E.
?ructosuria caus causes es naus nausea ea and and 7om 7omit itin ing g aft after er the the inge ingest stio ion n of of suc sucro rose se.. resu result ltss in in the the pres presen ence ce of redu reduci cing ng suga sugarr in in the the urin urine. e. is accomp ompanied nied %$ h$po h$pog gl$cemi emia. is a risk factor for cataracts. lead leadss to to the the accum accumul ulat atio ion n of of fru fruct ctos osee 1,p 1,pho hosp sphat hatee in in the the kidne kidne$ $.
&0. 3n the pentose pentose phosphat phosphatee path! path!a$ a$ he=os he=osee mono monophos phosphat phatee shunt shunt an an o=ida o=idati7 ti7ee decar%o=$lation reaction is catal$
4,phosphogl oglucona onate deh$dr h$dro ogenas nase glucose 4, 4,phos hosphate de deh$d h$drogenas nase phosphori%ose isomerase transaldolase transketolase
&1.
/hich /hich of of the the foll follo!i o!ing ng can can %e %e produ produced ced %$ the the non, non,o=i o=idat dati7e i7e part part of the pentos pentosee phosphate path!a$
A. B. C. D. E.
4,phosphogluconate galactose 1, 1,phosphate gl$ceraldeh$de &,phosphate lactose ?AD
&2. &2.
5hos 5hosph phor or$l $lat atio ion n cau cause sess the the acti acti7a 7ati tion on of
A. B. C. D. E.
p$ru7ate de deh$drogenase. gl$cogen s$nthase gl$cogen phosphor$lase" he=okinase. phosphoglucose iso isomerase.
&&.
8alactosemia
A. B. C. D. E.
is caus caused ed %$ a def defic icie ienc nc$ $ of of the the en<$ en<$me me lact lactas ase. e. is tre treat ated ed !it !ith ora orall h$ h$pogl pogl$ $cem cemic agen agentts. is acco accom mpani panied ed %$ lacto actose se int intoler oleran ance ce.. is asso associ ciat ated ed !ith !ith the the acc accum umul ulat atio ion n of gala galact ctit itol ol.. is due to the the act acti7 i7at atio ion n of of a spec specif ific ic gala galact ctos osee 1,p 1,phos hospha phata tase se..
6
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
&*.
3n a norm normal al !ell !ell fed fed indi indi7id 7idual ual the the conce concentr ntrati ation on of gl$coge gl$cogen n per gram gram of tissue tissue is greatest in the
A. B. C. D. E.
%rain. skeletal muscle. spleen. li7er. lung.
&.
The gl$ gl$coge cogen n %ranch %ranching ing en<$me en<$me is re#uir re#uired ed for for the the form formati ation on of gl$cos gl$cosidi idicc links links of of the the t$pe
A. B C. D E.
alpha 1,* alpha 1,2 %eta 1,* %eta 1,4 alpha 1,4
&4.
/hich /hich of the follo! follo!ing ing en<$mes en<$mes is is re#ui re#uired red for for BT( BT( the s$nthe s$nthesis sis and %rea %reakdo kdo!n !n of gl$cogen
A. B. C. D. E.
glucose 4,phosphatase phosphoglucomutase UD5,glucose p$ropho phosphor$lase ase gl$cogen %ranching en<$me gl$cogen isomerase
&6.
An infa infant nt died died from from heart heart failur failure. e. Autop Autops$ s$ re7e re7eale aled d an enla enlarg rged ed heart heart.. There There !as accumulation of gl$cogen in man$ tissues. The e7idence suggests a deficienc$ of
A. B C. D. E.
gl$cogen ph phosphor$lase. glucagon receptors. glucose 4,phosphatase gl$cogen phosphor$lase kinase. l$sosomal alpha glucosidase.
&9.
Acti7a Acti7atio tion n of phosph phosphopr oprote otein in phosphat phosphatase ase %$ insuli insulin n !ill !ill facili facilitat tatee the the
A. B. C. D. E
con7e n7ersion of of p$ p$ru7at 7ate to to gl glucose. o=id o=idat atio ion n of of fat fatt$ t$ acid acidss to to for form m ace acet$ t$ll coe coen< n<$m $mee A. A. h$drol$sis of of di disaccharides. formation of ketone %odies. the s$nthesis of gl$cogen.
9
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
&;.
/hich of the follo!ing molecules contains man$ sulfate groups
A. B. C. D. E.
(eparin ($aluronic acid 3nsulin Cellulose C$steine
*0. *0.
3den 3denttif$ if$ the the foll ollo!i o!ing str struct ucture ure CH2COOH I
HOCCOOH I CH2COOH
A. B. C. D. E.
8lucuronic acid Succinic acid :alic acid Citric acid =aloacetic acid
*1. *1.
/hic /hich h of the the fol follo lo!i !ing ng is is a gl$c gl$cos osam amin inog ogl$ l$ca can n
A. B. C. D. E.
am$lose gl$cogen starch chondroitin sulfate glucagon
*2. The en<$me en<$me lactas lactasee h$dro h$drol$< l$
glucose lactate fructose sucrose =$lose
;
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
*&. *&.
)AD5 )AD5 is a coen coen<$ <$m me for for the en<$ en<$me me
A. B. C. D. E.
gluc glucos ose, e,4, 4,ph phos osph phat atee deh$ deh$dr drog ogen enas asee p$ru7ate deh$drogenase succinate deh$drogenase lactat lactatee deh$dro deh$drogena genase se glucose o=idase
**. **.
/hic /hich h of the the fol follo lo!i !ing ng is is part part of of an ana%o ana%oli licc meta meta%ol %olic ic pat path! h!a$ a$
A. B. C. D. E.
Con7 Con7er ersi sion on of of gl$ gl$coge cogen n to glu gluco cose se 1,p 1,pho hosp spha hate te and and glu gluco cose se =id =idat atio ion n of of gl$ gl$ce cera ralldeh$ deh$de de &,ph &,phos osph phat atee ($drol$sis of sucrose ?or ?ormati ation of succ succiinic nic aci acid d fr from cit citric ric aci acid d Con7 Con7er ersi sion on of acet acet$ $l coen coen<$ <$me me A to malo malon$ n$ll coen coen<$ <$me me A
*.
/hich /hich of of the the foll follo!i o!ing ng ami amino no acids acids has a net net )E8A )E8AT T3E charge charge at p( p( 4.0 4.0
A. B. C. D. E.
asparagine. aspartic acid. gl$cine. histidine. t$rosine.
*4.
/hich /hich group groupss of %onds %onds are are e=pec e=pected ted to cont contri% ri%ute ute most most to sta%il sta%ilit$ it$ of hemo hemoglo glo%in %in UATE')A'F UATE')A'F structure structure
A. B. C. D. E.
peptide" di disulfide" h$ h$drogen disulfide" h$drogen" ester h$dr h$dro ogen gen" es ester" electrostati atic est ester" er" elec electtrost ostatic atic"" h$dr h$drop opho ho%i %icc electrostatic" h$dropho%ic" 7an der /aals.
*6.
α,(eli= structure is sta%ili
A. B. C. D. E.
7an der /aals h$drogen h$dropho%ic disulfide electrostatic
10
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
*9. A tr$pto tr$ptophan phan resi residue due on on the interi interior or of a protei protein n !ould !ould %e e=pec e=pected ted to to form form the strong strongest est h$dropho%ic %ond !ith !hich of the follo!ing residues A. B. C. D. E.
glutamate leucine aspartic acid histidine arginine
*;. 3n mammals gl$col$sis occurs in A. li7e li7err onl$ onl$ B. li7e li7err and and kidn kidne$ e$ C. e7er e7er$ $ cel cell D. %rai %rain n and and li7 li7er er E. musc muscle le and and %rai %rain n onl$ onl$.
0. A negati7e allosteric allosteric modifier of phosphofructokinase phosphofructokinase in the li7er li7er that that results results in the the inhi%ition of gl$col$sis is A. B. C. D. E.
A:5 ?ructo ?ructose se 2"4 2"4 %isp %isphos hospha phate te AT5 C$cl C$clic ic A:5 o=al o=aloa oace ceta tate te
1. The third third irre7ersi%le irre7ersi%le reaction in in gl$col$sis gl$col$sis that results in the the generation of AT5 is catal$
phospho phosphofru fructo ctokin kinase ase gl$cera gl$ceralde ldeh$d h$dee & 5 deh$d deh$drog rogenas enasee phophogl phophogl$ce $cerat ratee kinase kinase p$ru7 p$ru7at atee kin kinas asee gluc glucok okiinase nase
2. 3n gl$ gl$col$ col$sis sis"" the the num%e num%err of en<$mes en<$mes that that catal catal$
n e. T!o. Th re e . ?our. ?i7e. 11
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
&. 3n case casess of star7a star7atio tion n !hich !hich one one of the follo! follo!ing ing en<$mes en<$mes !oul !ould d %e increa increased sed in the the li7e li7er r and kidne$ A. gluc glucok okin inas asee B. he=okinase C. phos hospho phoenolp$ olp$rru7ate ate car%o=$ki =$kina nasse D. phosphofructokinase E. enolase *.
The fructo fructose se 1"4 %isphos %isphosphat phatase ase reacti reaction on in in glucon gluconeoge eogenes nesis is can %e inhi inhi%it %ited ed %$
A. B. C. D. E.
A:5. citrate. fructose 2"4 %isphosphate. p$ru7ate. glucose,1,phosphate.
.
3n glucon gluconeoge eogenes nesis is the acti7i acti7it$ t$ of of p$r p$ru7at u7atee car%o car%o=$l =$lase ase is stimul stimulate ated d %$
A. dih$dro dih$dro=$a =$aceto cetone ne phosphat phosphate. e. B. acet$l coen<$me A. C. lactate. D. gl$cerol. E. glucose. 4. 4.
Cort Cortis isol ol stim stimul ulat ates es the the e=p e=pre ress ssio ion n of of
A. gluc glucok okin inas ase. e. B. p$ru7ate ki kinase. C. he=okinase. D. glucose,4,phosphatase. E. glucose,4,phosphat hate deh$dr h$dro ogena genasse.
6. A. B. C. D. E.
An e=ample of a fatt$ acid !ith 19 car%ons and t!o dou%le %onds is oleic acid. stearic acid. erucic acid. linoleic acid. arachidonic acid.
12
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
9. /hich t! t!o t$ t$pes of of atoms are most li likel$ to %e fo found in in the region of of a lipid %ila$er that is most distant from the the a#ueous en7ironment A. B. C. D. E.
;. of gl$cogen
car%on and h$drogen car%on and o=$gen car%on and nitrogen o=$gen and phosphorus h$drogen and o=$gen
/hich of the follo!ing en<$me is is used in %oth the s$nthesis and %reakdo!n
A. B. C. D. E.
gl$cogen s$nthase phosphoglucomutase gl$cogen phosphor$lase am$lo,1"4 glucosidase gl$cogen %ranching en<$me
40.
/hich of the follo!ing compounds is a phospholipid
A. B. C. D. E.
trigl$ceride acetoacetate lecithin fructose 4,phosphate 4,phosphogluconate
41.
The rate,limiting st step in cholesterol s$nthesis is catal$
A. B. C. D. E.
acet$l coen
42.
An e=ample of a monounsaturated fatt$ acid is
A. B. C. D. E.
%ut$ric acid. p$ru7ic acid palmitic acid stearic acid oleic acid
1&
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
4&. =idation of e7en chain unsaturated fatt$ acids %$ the β,o=idati7e path!a$ produces less energ$ than the o=idation of the same length saturated fatt$ acids. The decrease in energ$ production is due to decrease in the num%er of A. B. C. D. E.
acet$l CoA molecules produced. )AD( molecules produced. ?AD(2 ?AD(2 molecules produced. )AD5( molecules that are produced AD5 molecules that are formed
4*.
3soen<$mes
A. B. C. D. E.
ha7e same amino acid se#uence. ha7e the same >m and ma= 7alue !hen con7erting a su%strate to the product. catal$
4.
3n D)A
A. B. C. D. E.
the pentose is deo=$ara%inose. there is a %eta gl$cosidic link %et!een the pentose and a %ase. guanine is %ase paired !ith th$mine. phosphates ha7e 2G&G phosphodiester links. the structure differs from that of ')A in that all %ases are meth$lated.
44.
The num%er of h$drogen %onds %et!een %ases is either
A. B. C. D. E.
one or three. t!o or four. one or t!o. three or four t!o or three.
46.
3n mature collagen t$pe 3
A. B C. D. E.
e7er$ third amino acid is gl$cine" the structure consists of a right,handed dou%le heli=. h$dro=$lation of histidines is re#uired to form strong cross links. cross links all ha7e the same structure as in elastin. the final steps of maturation take place in the c$tosol. 1*
Fundamentals of Biomedical Science A Sample EXAM #1
2014
For each of the following multiple choice uestions! choose the most appropriate answer"
49.
The o!r$ and Bradford Assa$s are colorimetric assa$s for
A. B. C. D. E.
D)A. ')A. gl$cogen. protein." fatt$ acids.
4;.
The most a%undant t$pe of protein in the %od$ is
A. B. C. D. E.
al%umen. hemoglo%in. collagen. m$osin. keratin.
60.
)AD5 is used as a coen<$me %$
A. B. C. D. E.
lactate deh$drogenase. p$ru7ate deh$drogenase. succinate deh$drogenase. 4,phosphogluconate deh$drogenase. alpha,ketoglutarate deh$drogenase.
1