LAPORAN PRAKTIKUM TEKNOLOGI SEDIAAN STERIL
PEMBUATAN SEDIAAN OBAT TETES MATA CHLORAMPHENICOL 0,5% YANG MEMPUNYAI PH =7,0 SEBANYAK 10 ML
Disusun O!" # 1$ )$ $ /$
Aii&n'i B&in(& P Aui& Aui& A(i' A(i'+& +& A Ni(i& Ri-.i I N& N& Pu'i Pu'i N
1)))101010*7 1)))10 1)))10101 101071 071 1)))1010107 1)))10 1)))10101 101075 075
BAGIAN FARMASETIKA FAKULTAS FARMASI UNIVERSITAS JEMBER MARET, 2015
I. TUJUAN PRAKTIKUM 1$ M!2&"&2i (&n (&3&' 2!&4u4&n 2!'(! s'!iis&si i'&si (&n s'!iis&si &s&" )$ M!23!&6&i 3!2u&'&n s!(i&&n &' '!'!s 2&'& s'!i 3H 7,0 (!n&n 3!n&2&"&n
&4'!isi(&
II. PRA FORMULASI 1$ Tin6&u&n &2&4is 4&2!ni4 8M&'in(&!# 117 (&n 9&2&4i II: E!4 u'&2& # &n'i&4'!i B&4'!is'&'i4 # '!"&(&3 !n'!&;'! (&n s'&3"+;;;us &u!us B&4'!isi( # '!"&(&3 s'$ Pn!u2ni&!$ N!iss$ M!nini'is,H$ In<&n-!
82&'in(&! *)00>3$)/1: E!4 s&23in # !&4si "i3!s!nsi'i '!2&su4 &s"!s, (!2&2, &ni(!2& is& '!6&(i, 4"ususn+& s!'!&" 3!nun&&n '3i4& 82&'in(&! *)00>3$)/1: Kn'&in(i4&si # 82&'in(&! *)00>3$)/0:
- P&si!n (!n&n i<&+&' "i3!s!nsi'i?i'&s &'&u !&4si '4si4 3&(& 4&2!ni4 - Ti(&4 !" (i!i4&n s!;&& sis'!2i4 un'u4 in!4si in&n &'&u un'u4 3i&4sis - P&2 3!n&'&n !u&n (&n !4!3&n6&n&n - S!"&usn+& 'i(&4 (iun&4&n 3&(& 3&si!n (!n&n (!3!si su2su2 'u&n &'&u (is4isi& (&&" - P!nun&&n 4&2!ni4 (i"in(&i s!;&& 4!"&2i&n (&n (&3&' 2!n&nu i2uni'&s (&n 'i(&4 !" (i!i4&n s!&2& &4'i i2unis&si P!"&'i&n (&n 3!in&'&n # P&(& 3!nun&&n 6&n4& 3&n6&n s!&i4n+& (i&4u4&n 3!2!i4s&&n "!2&'i s!;&& !4&&$ H&'i@"&'i 3!nun&&n 3&(& 3!n(!i'& (!n&n &nu&n && in6&, <&ni'& "&2i (&n 2!n+usui, &+i 3!2&'u (&n &+i +&n &u &"i 82&'in(&! *)00>3$)/0:
)$ Tin6&u&n si&' isi4& 4i2i& 82&'in(&! *)00>3$)>: &$ K!&u'&n # 1#/00 (&&2 &i, 1# ),5 (&&2 !'&n >5% P, su4& &u' (&&2 42 P (&n (&&2 !'! P, 1#7 (&&2 33i!n i4 P, P&4'is 'i(&4 &u' (&&2 3!'&'u2 (&n 2in+&4 n&&'i 8M&'in(&!# 11*:$ $ S'&ii'&s - T!"&(&3 ;&"&+&# 'i(&4 s'&i P!2&3&&n 4&2!ni4 8!+! (3s 10 2 2L, (&3& s&' PH 7,0: '!"&(&3
-
;&"&+& 2!n!&4&n (!&(&si 0% (&&2 <&4'u /5 2!ni'$ T!"&(&3 su"u# 'i(&4 s'&i
D&&2 &i &4&n '!"i(isis /% 83!2&n&s&n 100C 0 2!ni': (&n 10% 83!2&n&s&n 115C, 0 2!ni':$ P&(& PH 7,) !i" ;!3&' '!(!&(&si (&i3&(& PH
-
/, 83!2&n&s&n 100C1)0C: T!"&(&3 PH# PH &u'&n 6!nu" /,5@7,5 PH s'&ii'&s 3'i2u2 *,0 89I I,1>>5:$ S'&i '!"&(&3 &u'&n n!'& (&n &s&2, ;!3&' us&4!" &u'&n &4&i 8R!2in'n:$ S'&i 3&(& PH +&n u&s un'u4
-
&u'&n &i 8PH )@7: T!"&(&3 4si!n# 'i(&4 s'&i$
;$ C&& s'!iis&si &"&n S!(i&&n (i3&n&s4&n 3&(& su"u 100C s!&2& 0 2!ni' (!n&n 3!(i4si 4!"i&n&n "&n+& ,*%$ P!2&n&s&n >@100% s!&2& 0 2!ni' 3&(& s!(i&&n '!'!s 2&'& 'i(&4 &4&n 4!"i&n&n 3'!nsi !i" (&i 10% 8M&'in(&!# 117: ($ In423&'iii'&s @ D!n&n 3&&s!'&2
# 2!nuun4&n <&4'u 3&u" (&n 4i!ns
@ D!n&n 4n'&s!3si & # 2!nuun4&n !i4&si 4n'&s!3si & @ D!n&n (iu!'i;
# 2!nin4&'4&n !4s4!si 4&2!ni4 8us!2i(:
!$ C&& 3!nun&&n Dsis u2u2 un'u4 in!4si ;u&, 3'&2i4, 4&2!ni4 0,5% (sis 1@)'!'!s 'i&3 ) 6&2 un'u4 / 6&2 3!2&4&i&n 3!'&2&, 'i&3 / 6&2 un'u4 3!2&4&i&n s!'!&"n+&
III. FORMULASI 1$ P!2&s&&"&n (&n 3!n+!!s&i&n PH s!(i&&n "&us (iu&' 2!n(!4&'i PH isiis un'u4 2!n;!&" ii'&si H&& PH 2&'& s&2& (!n&n PH (&&" +&i'u 7,/ 8Lu4&s, )00*:$ H&& PH
'!'!s 2&'& 4&2!ni4 &n'&& 7@7,5 3&(& &u'&n (&3& 89I I, 1>>5:$ S!"in& 3&(& s!(i&&n '!'!s 2&'& (i'&2&"4&n u! &' +&n 2!2ii4i !n'&n PH *,@>,1 8Lu4&s, )00*: && (i"&si4&n PH s!su&i ;&i&n isiis 2&'&$ K&2!ni4 'i(&4 s'&i 3&(& 3!2&n&s&n K&2!ni4 3&(& &i &4&n '!"i(isis /% 83!2&n&s&n 100C, 2!ni': (&n 10% 83!2&n&s&n 110C, 0 2!ni':$ P&(& PH 7,) !i" ;!3&' '!(!&(&si (&i3&(& PH /, 83!2&n&s&n 100C1)0C:$ K&2!ni4 4u&n &u' (&&2 &i A3&i& (ii"&' (&i 4!&u'&nn+& 2&4& 4&2!ni4 s&n&' su4& &u' (&&2 &i 81#/00:, s!"in& un'u4 2!nin4&'4&n 4!&u'&n+& (i'&2&"4&n &'&u (i&u'4&n (&&2 (&3& &', 4&!n& (&3& &' 6u& !unsi un'u4 2!nin4&'4&n 4!&u'&n$
K!2un4in&n '!6&(i 4n'&2in&si 2i4&nis2! 4&!n& '!2&su4 s!(i&&n (sis &n(&
Un'u4 2!n&n'isi3&si "& '!s!u' 2&4& 3!u (i'&2&"4&n &4'!isi(&$ P&(& 3&4'i4u2 ini (i3ii" !ni 2!4ui ni'&' (!n&n 4ns!n'&si 0,001@0,00)%$ Di3ii" !ni 2!4ui ni'&' 4&!n& 2!2ii4i !n'&n PH +&n u&s$ S!&in i'u
3!n&2&"&n &4'!isi(& 6u& (&3&' 2!nin4&'4&n ni&i SAL$ )$ 92u&si R ;&23"!ni; 500 2 Bi; &;i( 1,5 B& 00 2 P"!n+ 2!;ui; ni'&'! ) 2 F&'! in6!;'in &( 100 2 $ P!"i'un&n !&' (&n ?u2! u2! +&n '!'!& 3&(& 4!2&s&n &(&&" 10 2, 4&!n& s'!iis&si 2!nun&4&n i'&si, (i4"&<&'i4&n &(&n+& &"&n +&n '!'in&, 2&4& 3!ni2&n&n (i!i"4&n 50%$ P!ni2&n&n &"&n = 752 - K&2!ni4 = 50021002 15 2 = 1,51002 15 2 = ))52 - Bi; &;i( = 0021002 152 = /52 - B& Ti2&n = 50 2 &u (i'&2&"4&n 5 2 !ni 2!4ui ni'&' 0,00)% &( &u'$
-
= /,5 2 8(i3i3!' /,5 2: P"!n+ 2!;ui; ni'&'! = )21002 152 = 0,2 P!n!n;!&n (!n&n 2!ni2&n 50 2 &u (i'&2&"4&n &. in6!4si 50 2 &u (i3i3!' 0, 2$ P&(& 3!;&&n, !ni 2!4ui ni'&' '!&" (i!i4&n (&&2
-
!n'u4 '!&u'$ F&'! in6!;'in A. 3 in6!4si (i'&2&"4&n &( 15 2 +&n '!'!& 3&(& s!(i&&n = 10 2 4!!i"&n 0,5 2 89I I, 1>>5:$ &(i s!(i&&n +&n (i2&su44&n 3&(& ' &(&&" 10,5 2$
($ C&& s'!iis&si &"&n S!(i&&n (is'!iis&si (!n&n 2!nun&4&n s'!iis&si i'&si$ IV. 1.
PELAKSANAAN Penyiaan A!a" a. A!a" yan# $i#%na&an $an 'a(a )"e(i!i)a)i
N
N&2& &&'
u2&"
U4u&n
S'!iis&si
F&4'u
1 )
K&;& &6i K&;& &6i P!n&(u4
) 1 )
;2 5;2
O?!n@10C O?!n@10C O?!n@10C
0J 0J 0J
/ 5 * 7 > 10 11 1) 1 1/
G!&s !4! S!n(4 &2 Pins!' E!n2!+! B' '!'!s ;4&' Pi3!' '!'!s 3!n(!4 Cn K!'&s s&in G!&s u4u Pi3!' ' '!'!s T&i
) 1 ) 1 1 ) 1 ) 1 1 .$s
502
502 102 5;2
O?!n@10C O?!n@10C O?!n@10C O?!n@10C O?!n@10C Au'4&@115C Au'4&@115C Au'4&@115C Au'4&@115C Au'4&@115C Au'4&@115C
0J 0J 0J 0J 0J 0J 0J 0J 0J 0J 0J
*. Pen'%'ian, en#e(in#an, $an e+*%n#&%)an a!a" @ P!n;u;i&n &&' !&s
M!n;u;i &&' !&s (!n&n &i (&n HC !n;! M!!n(&2 (&&2 &u'&n '!3 1% (&n N& )CO 0,5% 8&&: (&n (i(i"4&n s!&2& 1 6&2 U&ni &( &u'&n 6!ni" 82&4si2& : M!2i&s (!n&n &.u&(!s' s!&n+&4 @
P!n;u;i&n &&' &u2uniu2 M!n(i(i"4&n &&' &u2uniu2 (&&2 '!3 1% s!&2& 10 2!ni' M!!n(&2 (&&2 &u'&n N&)CO 5% s!&2& 5 2!ni' M!2i&s (!n&n &.u& 3&n&s 2!n&i M!n(i(i"4&n (!n&n &i 15 2!ni' 4!2u(i&n (ii&s M!n(i(i"4&n (!n&n &.u&(!' 15 2!ni' M!2i&s (!n&n &.u&(!s' s!&n+&4
@
P!n!in&n (&n 3!2un4us&n M!n!in4&n &&' (i ?!n 3&(& su"u 100@105 0C s!&2& 10 2!ni' 8(&&2 4!&(&&n '!&i4: M!n(inin4&n (&n un4us (!n&n &u2uniu2 i &n4&3 )
'. S"e(i!i)a)i a!a"
S'!iis&si &&' (!n&n 2!'(! 3&n&s 4!in 2!nun&4&n ?!n 3&(& su"u 10 C s!&2& 0 2!ni'$ @ F&4'u 3!2&n&s&n @ F&4'u 4!s!'i2&n&n @ F&4'u 3!2in&s&&n @ T&2&"&n <&4'u un'u4 6&2in&n s'!ii'&s @ F&4'u 3!n(inin&n T'& <&4'u s'!iis&si
= 2!ni' = 2!ni' = 0 2!ni' = 2!ni' = 2!ni' = 2!ni'
S'!iis&si &&' (!n&n 2!'(! 3&n&s &s&" 2!nun&4&n &u'4& 3&(& su"u 1)1C s!&2& 15 2!ni'$ @ F&4'u 3!2&n&s&n @ F&4'u 3!n!u&&n u(&& @ F&4'u 2!n&i4 @ F&4'u 4!s!'i2&n&n @ F&4'u 3!2in&s&&n @ T&2&"&n <&4'u un'u4 6&2in&n s'!ii'&s @ F&4'u 3!nuun&n @ F&4'u 3!n(inin&n T'& <&4'u s'!iis&si 2. a(a &e(-a
= 2!ni' = 2!ni' = 2!ni' = 2!ni' = 15 2!ni' = 2!ni' = 2!ni' = 2!ni' = 2!ni'
M!n+i&34&n &&' (&n &"&n
&$ P!2u&'&n (&3& &' PH 7,0 ' '!'!s ;4&' 10,5 2 M!n4&i&si S!6u2&" ))52 As&2 B&' (i'i2&n, &u (i&u'4&n (&&2 52 &u'&n 9!ni M!4ui Ni'&' 0$00)% S!6u2&" 50 2 B& (i'i2&n, (i&u'4&n 4! (&&2 &u'&n 9!ni M!4ui Ni'&' 0,00)% 5 2, 3i3!' /,5 2 L&u'&n B& (&n As&2 B&'
(i;&23u, (&n (iu4u &( 3H 7,0 $ P!2u&'&n s!(i&&n '!'!s 2&'& L&u'&n D&3& B&' 3H 7 S!6u2&" 75 2 K&2!ni4 (i'i2&n, &u (i2&su44&n 4!(&&2 !&4! &ss
75 2 K&2!ni4 (&&2 B!4! G&ss (i'&2&" &u'&n (&3&, &u (i&(u4 &( &u' i& 3!u (!n&n 3!2&n&s&n 50C L&u'&n (&3& K&2!ni4 Di'&2&" (!n&n !ni 2!4ui ni'&' 0,00)% &( 15 2, &u (i&(u4, (&n (i;!4 PH L&u'&n (&3& K&2!ni4 9!ni M!4ui Ni'&' 0$00)% Dis&in (!n&n 2!2&n 3!i'! (&n 2!2&n! i'! 1$) 2 (i LA9 L&u'&n (&3& K&2!ni4 9!ni M!4ui Ni'&' 0$00)% '!&" (is&in (!n&n 2!2&n 3!i'! (&n 2!2&n! i'! 1$) 2 (i LA9 (i2&su44&n s!&n+&4 10,5 2 4! (&&2 ' 89I I,1>>5:, 4!2u(i&n ' (i'u'u3 &3&' S!(i&&n '!'!s 2&'& 4&2!ni4
. Ke+a)an
KOMPOSISI M!n&n(un K&2!ni4 $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$ $$$$$$$$ 0$5% 9ARMAKOLOGI K&2!ni4 2!u3&4&n &n'i&4'!i (!n&n s3!4'u2 u&s, (&3&' 2!n&'&si in!4si su3!isi& 3&(& 2&'& +&n (is!&4&n !" 2i4&nis2!$ INDIKASI M!n&'&si in!4si su3!isi&is 3&(& 2&'& +&n (is!&4&n !" 2i4&nis2! KONTRAINDIKASI P!n(!i'& +&n 2!n&&2i "i3!s!nsi'i?i'&s$ DOSIS DAN CARA PEMAKAIAN T!'!s4&n ) '!'!s 3&(& 2&'& +&n s&4i' @/ 4&i s!"&i$ PERINGATAN DAN PERHATIAN A& 'i(&4 '!4n'&2in&si 6&&&" su3&+& u6un ' 'i(&4 '!4!n& '&n&n &'&u su&'u !n(&$ Tu'u3 4!2&i ' s!'!&" 3!2&4&i&n$ Hin(&i 3!nun&&n !ns& 4n'&4 4!'i4& 2!nun&4&n &' ini$ Bi& s!'!&" ) "&i in!4si 'i(&4 2!2&i4 s!!& 4nsu&'si4&n (!n&n (4'!$
/. B()%(
E9EK SAMPING M&'& '!&s& 3!(i", '!&4&, (&n "i3!!2i& (&3&' '!6&(i &4i&' 3!nun&&n +&n !!i"&n$ KEMASAN B' !isi 102 N$ R! # SRK7/71)/B) SIMPAN DI TEMPAT SEUK, KERING DAN TERLINDUNG DARI CAHAYA B&';" # 571/1 M$(&'! # A3 J15 E3$(&'! # A3 1>
5. E"i&e"
V.
ASIL PENGAMATAN &$ 3H s!(i&&n = 7
$ u2 s!(i&&n +&n (iu&' = 10,5 2 K&!n& un'u4 s!(i&&n 10 2 , 4!!i"&n ?u2 +&n (i&n6u4&n &(&&" 0,5 2 89&2&43! In(n!si& I, 10//: ;$ S'!iis&si S!(i&&n (!n&n Au'4& Su"u 1)1⁰C s!&2& 15 M!ni' F&4'u 3!2&n&s&n # 10 2!ni' • F&4'u 3!n!u&&n u(&& # 0 2!ni' • F&4'u 2!n&i4 # 0 2!ni' • F&4'u 4!s!'i2&n&n # 10 2!ni' • F&4'u 3!2in&s&&n # 0 2!ni' • F&4'u '&2&"&n 6&2in&n s'!ii'&s # 5 2!ni' • F&4'u 3!nuun&n # 0 2!ni' • F&4'u 3!n(inin&n # 7 2!ni' • T'& F&4'u # *) 2!ni' • Ps!s s'!iis&si (i2u&i 3u4u 15$0 s&23&i (!n&n 3u4u 1*$05
VI.
PEMBAASAN
P&(& 3&4'i4u2 4&i ini (i&4u4&2 3!2u&'&n s!(i&n '!'!s 2&'& 4&2!ni4 0,5% +&n 2!23un+&i 3H 7 s!&n+&4 10 2$ S!(i&&n '!'!s 2&'& &(&&" s!(i&&n s'!i !u3& &u'&n &'&u sus3!nsi +&n (iun&4&n 3&(& 2&'& (!n&n ;&& 2!n!'!s4&n &' 3&(& s!&3u' !n(i 2&'& (is!4i'& 4!3&4 2&'& &'&u & 2&'&$ S'!ii'&s &(&&" 3!s+&&'&n +&n s&n&' 3!n'in (&&2 3!2u&'&n &u'&n 2&'&, 4&!n& 3&(& &u'&n '!s!u' (i2un4in4&n
2!2&<& &n+&4 &nis2! +&n !&"&+&, ;n'"n+& Pseuodomonas aeroginosa$ In!4si 2&'& !" Pseuodomonas aeroginosa ini (&3&' 2!2u&' 4!u'&&n$ B&"&n &4'i +&n (iun&4&n (&&2 3&4'i4u2 ini &(&&" 4&2!ni4$ A(& 6!nis 4&2!ni4, +&i'u 4&2!ni4 &s!, 4&2!ni4 3&2i'&' (&n 4&2!ni4 s(iu2 su4sin&'$ K&2!ni4 su4sin&' (&n 3&2i'&' 2!u3&4&n 2u&si 3&' 'i(&4 &4'i &n'ii'i4 +&n 2!2!u4&n 3!2!;&"&n uus !s'! (&i s!n+&<& in(u4 un'u4 2!2!&s4&n 4&2!ni4 +&n !si&' &n'i&4'!i& &4'i 8B!;"2!n,1>>*:$ P&(& 3&4'i4u2 4&i ini (i3ii" 4&2!ni4 &s!, 4&!n& s!(i&&n +&n (iu&' (i'u6u4&n un'u4 3!nun&&n 3&(& 2&'&$ M&'& 'i(&4 2!23un+&i !n-i2 "i(i'i4 s!3!'i 3&(& s&u&n ;!n&, s!"in& un'u4 s!(i&&n '!'!s 2&'& 'i(&4 (&3&' (i!i4&n 4&2!ni4 3&2i'&' 2&u3un su4sin&' 4&!n& 'i(&4 &(& !n-i2 +&n 2!2!;&" 4!(u&n+& 3&(& 2&'&$ K&2!ni4 2!u3&4&n &n'ii'i4 !si&' &4'!is'&'i4 (&n 2!23un+&i s3!4'u2 u&s$ K&2!ni4 !!4'i '!"&(&3 i4!'si& (&n 4n6un'i?i'is &4u' +&n (is!&4&n !" 2i4&nis2!, '!2&su4 Pseudomonas sp 4!;u&i Pseudomonas aeroginosa$ S!n+&<& ini 6u& !!4'i un'u4 3!n&'&n in!4si !&' +&n (is!&4&n !" &4'!i &2 3si'i (&n &2 n!&'i$ E!4 u'&2& (&i 4&23"!ni4 3&(& s!(i&&n '!'!s 2&'& &(&&" s!&&i &n'ii'i4 s3!4'u2 u&s (!n&n ;&& 2!n&nu sin'!sis 3'!in (&n !si&' &4'!is'&'i4$ P&(& 3!n+&4i' 2&'& (iun&4&n un'u4 2!n&'i 4n6un'i?is 4n6un'i?i'&s$ E!4 s&23inn+& &(&&" !'i43!ni&, &n!2i& &3&si&, &nu&n 3!ni"&'&n, u&2, (!2&2, (&n &ni (!2&$ P!2&3&&n 4&2!ni4 8!+! (3s 10 2 2L, (&3& s&' PH 7,0: '!"&(&3 ;&"&+& 2!n!&4&n (!&(&si 0% (&&2 <&4'u /5 2!ni'$ S!"in& un'u4 2!n"in(&i 3s!s 'isis (iun&4&n <&(&" s!(i&&n +&n !&3 '!in(un (&i 3&3&&n ;&"&+& s!;&& &nsun, 2is&n+& 2!nun&4&n <&(&" !<&n& ;4&'$ S!(i&&n (isi23&n (i'!23&' +&n '!in(un (&i ;&"&+&, s'!i, (&n 4!(&3 u(&& (British Pharmacopoeia, 2001). B!&nsunn+& "i(isis 4&2!ni4 '!4&'&isis &s&2 u2u2&s& u2u2, '!'&3i 3&(& 4is&&n 3H ) s&23&i 7, &6u !&4sin+& 'i(&4 '!&n'un PH$ S3!si!s 3!n4&'&is&si &(&&" &s&2 u2u2 &'&u &s& u2u2 +&n '!(&3&' 3&(& &u'&n (&3& +&n (iun&4&n 4"ususn+& 3&(& in 2n"i(!n s&', &s&2 &s!'&' 'i(&4 '!(issi&si, s!'& in &s&2 2n"i(!n (&n (i"i(!n si'&' (&3&' 2!n4&'&isis 3s!s (!&(&si$ Di&<&" 3H ), "i(isis '!4&'&isis in "+(!n s3!sii4 2!2!&n 3!&n&n !s& 3&(& '!6&(in+& (!&(&si 4&2!ni4$ O&' ini s&n&' 'i(&4 s'&i (&&2 su&s&n& &s&, (&n !&4sin+& '!i"&' '!4&'&isis &i4 &s&2 2&u3un &s& s3!sii4 8Cnns, 1>>):
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2!nu&n&4&n &u'4& (&3&' (i&4u4&n 3&(& su"u +&n !n(&" s!4i'& > 100 C s!&2& 0 2!ni' (!n&n ;&& 4&'u3 &u'4& (ii&4&n '!u4& (!n&n 3!n&2&"&n -&' &4'!isi(& (i4!'&"ui "&n+& '!6&(i (!&(&si s!!s& @ /% s!(&n&4&n s'!iis&si 3&(& su"u 115C s!&2& 0 2!ni', (&3&' 2!n&4i&'4&n 10% @ 15 % 4&2!ni4 '!(!&(&si 8Cnns (44$, 1>*:$ K&2!ni4 s'&i '!"&(&3 3!n&u" su"u &i4 (&&2 !n'u4 4is'& 2&u3un &u'&n$ P!n(i(i"&n (&&2 &i s!&2& 5 6&2 'i(&4 2!us&4 &4'i?i'&s 2i4&n+&$ B!(&s&4&n "&si 3!n&2&'&n 3&4'i4u2 (i"&si4&n <&4'u 4!s!'i2&n&n s'!iis&si 4&2!ni4 &(&&" 10 2!ni'$ K&2!ni4 'i(&4 s'&i '!"&(&3 ;&"&+& !" 4&!n& i'u un'u4 2!n;!&" !&4si 'isis 2&4& 2!nun&4&n <&(&" s!(i&&n +&n 'i(&4 '!2us ;&"&+&$ B' !<&n& ;4'& (i4!'&"ui 2&23u !'in(&4 s!&&i 3!in(un ;&"&+& +&n 3&in &i4$
VII. KESIMPULAN S!(i&&n '!'!s 2&'& &(&&" s!(i&&n s'!i !u3& &u'&n &'&u sus3!nsi +&n (iun&4&n •
3&(& 2&'& (!n&n ;&& 2!n!'!s4&n &' 3&(& s!&3u' !n(i 2&'& (is!4i'& 4!3&4 •
2&'& &'&u & 2&'&$ P!2ii"&n 4&2!ni4 &s!, 4&!n& s!(i&&n +&n (iu&' (i'u6u4&n un'u4
•
3!nun&&n 3&(& 2&'&$ E!4 u'&2& (&i 4&23"!ni4 3&(& s!(i&&n '!'!s 2&'& &(&&" s!&&i &n'ii'i4 s3!4'u2 u&s (!n&n ;&& 2!n&nu sin'!sis 3'!in (&n !si&' &4'!is'&'i4$ P&(& 3!n+&4i' 2&'& (iun&4&n un'u4 2!n&'i 4n6un'i?is 4n6un'i?i'&s$ E!4 s&23inn+& &(&&" !'i43!ni&, &n!2i& &3&si&, &nu&n 3!ni"&'&n, u&2, (!2&2, (&n &ni (!2&$
• •
#apar yan$ dipilih dalam formulasi adalah dapar %orat. Pen$aet yan$ dipilih adalah enil merkuri nitrat aktif pada spektrum pH yan$ luas melaan
%akteri dan *amur pada larutan
netral sampai alkali, serta efektif *u$a *ika di$unakan pada pH yan$ sedikit asam. enil merkuri nitrat meman$ %iasanya di$unakan terutama untuk sediaan optalmik. +enyaa ini memiliki aktitas %akterisidal dan fun$isidal. ktiitasnya akan menin$kat den$an
menin$katnya pH alaupun pada pH ke %aah diketahui fenil merkuri nitrat memiliki aktiitas melaan Pseudomonas aeru$inosa •
P&(& 3!2u&'&n s!(i&&n '!'!s 2&'& 4&2!ni4 ini, 3&(& '&"&3 &4"i 3!2u&'&n &(&&" i'&si (!n&n 2!nun&4&n 2!2&n! i'! 0,/5 2 (&n s'!iis&si (!n&n
•
&u'4& 3&(& su"u 1)1 ⁰C s!&2& 15 2!ni'$ K&2!ni4 'i(&4 s'&i '!"&(&3 ;&"&+& !" 4&!n& i'u un'u4 2!n;!&" !&4si 'isis 2&4& 2!nun&4&n <&(&" s!(i&&n +&n 'i(&4 '!2us ;&"&+&$ B' !<&n& ;4'& (i4!'&"ui 2&23u !'in(&4 s!&&i 3!in(un ;&"&+& +&n 3&in &i4$
DA9TAR PUSTAKA
Anni2$ 1>>5$ Farmakope Indonesia IV $ &4&'& # D!3&'!2!n K!s!"&'&n RI Ans!, H$C, 1>>, Pengantar Bentuk ediaan Farmasi! edisi ke"#$ &4&'& # UI P!ss B!;"2&n, Ki!2&n (&n A?in, N!sn$ 1>>*$ $elson Te%tbook of Pediatrics &thedition. S&un(!s C23&n+,P"i&(!3"i&$ Cnns, K!nn!'" A$, (44$1>*$ 'hemical tability of Pharmacuticals ( A )anbook of Pharmacist $ C&n&(& # Li&+ Cn!ss C&'&in in Pui;&'in D&'!$ Cnns KA, 1>>)$ tabilitas *imia+i ediaan Farmasi$ E(isi K!(u&$ S!2&&n# IKIP S!2&&n P!ss Lun(, F$, 1>>/, The Pharmaceutical 'ode%, )0'" !(i'in, P"P, Ln(n$ i"', R$, 1>>/ ! Buku Pela,aran Teknologi Farmasi, G&(6&" M&(& Uni?!si'+ P!ss, Y+&4&'&$ R
S+&", Kuni&<&n$ )00*$ 1,i tabilitas ediaan Tetes Mata *loramfenikol Menggunakan apar Fosfat ibandingkan ediaan Tetes Mata *loramfenikol Menggunakan apar Borat engan Metode 1,i ipercepat. Uni?$P&(6&6&&n$ T"! (!3&'!2!n' "!&'", s;i& s!?i;! &n( 3ui; s&!'+$ )001$ British pharmacopeia$ T"! s'&'in!+ i;!,n(n
LAMPIRAN
P!ni2&n&n As&2 B&'
D&3& B&' 7 L&u'4&n (&&2 5 23H &u'&n !ni 2!4ui ni'&', 3i3!' /,5 2
L&u'4&n (&&2 5 2 &u'&n !ni 2!4ui ni'&'
P!ni2&n&n B& P!ni2&n&n K&2!ni4
