MCQ-Series
Practice Test II
Basic Medical Science Time: 1 hr
Microbiology Email:
[email protected] Total Marks: 100 | Pass Mark: 60
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Multiple Choice Questions
1. Roundwo Roundworm rmss belo belongs ngs to: to: A Cestodes
C Trematodes
Nematodes des B Nemato
D Intestinal protozoa
2. Match the Type II Restriction Endonucleases with their correct correct Recognition Recognition Sequences on on the 3´ end: A.
BamH BamHI
A. G- T
B.
EcoR EcoRI
B. A-G
C.
Hind Hind III
C. G-A
D.
Sal I
D. G-G
E.
Pst I
E. A-A
3. Mechanism Mechanism of action action of Chloram Chlorampheni phenicol: col: A Cause misreading of m-RNA code
C Cause leakage from cell membranes
B Inhibit protein synthesis
D Interfere with DNA function
4. The causativ causativee agent of Epidem Epidemic ic typhus typhus is: is: A Rickettsia typhi
C Rickettsia prowazekii
B Rickettsia akari
D Rickettsia rickettsii
5. The most most common common life-threatening life-threatening invasive fungal infection worldwide: A Aspergillosis
C Blastomycosis
B Cryptococcosis
D Mucormycosis
6. Disease Disease due to eatin eating g undercoo undercooked ked beef: beef: A Taeniasis
C Gnathostomiasis
B Sarcocystosis
D Diphyllobothriasis
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MCQ-Series
Practice Test II
Microbiology
7. All of the followin following g are methods methods for detecti detecting ng microbi microbial al DNA except: A DNA microarrays
hybridization C Direct hybridization
B ELISA
D PCR
8. Highest case fatality is associated associated with which form of encephalitis? encephalitis? A Western equine encephalitis
C Eastern equine encephalitis
B St Louis encephalitis
D Japanese encephalitis
9. Zygomycosis Zygomycosis may may be caused by all of the following organisms organisms except: A Absidia
C Aspergillus
B Rhizopus
D Mucor
10. Which of the following following is not a normal microbiota microbiota of the the small small intestine? intestine? A Mycobacterium spp.
Peptostreptococcus spp. C Peptostreptococcus
B Bacteroides spp.
D Enterobacteriaceae
11. Nyst Nystat atiin is is a A Polyene antibiotic
Nitrobenz enzene ene deri derivat vativ ivee C Nitrob
antibiotic B Glycopeptide antibiotic
D Polypeptide antibiotic
12. Toxoplasm Toxoplasmaa belong belongss to to which which Class? Class? A Microspora
C Sarcodina
B Haematozoa
D Coccidia
13. Asexual reprod reproducti uctive ve structures structures of fungi includ includee all except: A Sporangiospores
C Mitospores
B Ascospores
D Conidiophores
14. The Cell Cell Surface Surface Protein Protein of of Poliovi Poliovirus: rus: Intercellular adhesion molecules molecules A Intercellular (ICAMs)
C Immunoglobulin superfamily D Receptor for the C3d complement prote protein in
B Acetylcholine receptor on neurons 15. Autoclave Autoclave can be be used for steril sterilizat ization ion of: of: A Glassware
C Powders
B Surgical instruments
D Oily substances
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MCQ-Series
Practice Test II
Microbiology
16. Entamoeba Entamoeba histolyt histolytica ica is a/an A Protozoa
C Amoeba
B Sporozoa
D Flagellate
17. Which of the following following antibiotics antibiotics is derived derived from mold or moulds? moulds? A Cefoxilin
C Tunicamycin
B Puromycin
D Aztreonam
18. Patients with complement complement component deficiencies suffer from: from: A Severe combined immunodeficiency disease
C Chronic granulomatous disease D Ataxia-telangiectasia
B Systemic lupus erythematosus 19. Which Which of the the following following do do not have have Ribosom Ribosomes? es? A Protozoa
C Bacteria
B Fungi
D Virus
20. All of the following involves involves immune immune complex complex hypersensitivity hypersensitivity reactions except: except: A Contact dermatitis.
phenonmenon C Arthus phenonmenon
B Serum sickness
D Pigeon fancier's disease
21. Tricho Trichom monas onas are classi classifi fied ed as: A Apicomplexa
C Flagellates
B Ciliates
D Sporozoa
22. The only microbe microbe that lacks a cell wall but has sterols sterols in their cytoplasmi cytoplasmicc membrane: membrane: A Protozoa
C Mycoplasma
B Fungi
D Bacterium
23. In those who suffer suffer from diabetes, Clostridium Clostridium perfringens usually colonizes colonizes only their: their: A nostrils
C urethra
perianal al region region B perian
D conjunctiva
24. "Veroto "Verotoxin xin"" is produc produced ed by: by: A Enteroinvasive E coli (EIEC)
C Enterotoxigenic E coli(ETEC)
B Enterohemorrhagic E coli (EHEC)
D Enteropathogenic E coli(EPEC)
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MCQ-Series
Practice Test II
Microbiology
25. Which of the following following statements statements regarding Lymphocytic Lymphocytic Choriomeningitis Choriomeningitis is/are correct? correct? A mortality rate 1-10%
C due to Sin Nombre virus infection
B natural vector is a deer mouse
D incubation period is 1-2 weeks
26. The causativ causativee pathogen pathogen of of Cats scrat scratch ch disease: disease: A F pedrosoi
C E floccosum
B B henselae
D S gordonii
27. Most effective effective method method for detection detection of HBV antigens and antibodies antibodies in a patient’s patient’s serum: serum: A Complement fixation
C Enzyme-linked immunosorbent assay
B Latex agglutination test
D Direct hemagglutination
28. Autoclave Autoclave uses uses ________ ________ for for steril sterilizat ization. ion. A Ultraviolet light at 265 nm energy
C Boiling water at 100°C for 2 hr+
B Hot air oven at 160°C for 2 hr
D Pressurized steam at 121°C for 15 min
29. Antigenic Antigenic determ determinan inants ts "Forssman "Forssman antigen" antigen" is characterist characteristic ic of A Pseudomonas aeruginosa
Histoplasma capsulatum C Histoplasma
pneumoniae B Streptococcus pneumoniae
D Moraxella catarrhalis
30. Match the following following Viruses Viruses with their corresponding Cell Surface Proteins: A.
Herpes simplex virus, type 1
A. CD46 complement regulator protein
B.
Hepatitis A virus
B. Sialic acid-containing glycoprotein
C.
Measles virus
C. Acetylated sialic acid on glycoprotein
D.
Rotavirus
D. Alpha 2-macroglobulin
E.
Influenza A virus
E. Fibroblast growth factor receptor
31. Which of the following organisms organisms rarely produces infection infection in in human human beings? A Pasteurella pneumotropica
C Pasteurella ureae
B Pasteurella multocida
D Pasteurella haemolytica
32. Mechanism Mechanism of action action of Chloram Chlorampheni phenicol: col: binds to 30S 30S subuni subunitt A binds
C inhibits protein biosynthesis
B inhibits translocation step
D causes misreading of genetic code
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MCQ-Series
Practice Test II
Microbiology
33. All of the followin following g are produced produced by streptococ streptococcus cus pyogenes pyogenes except: except: A streptokinases
C streptolysin O
B Exfoliatin
D streptolysin S
34. Incubatio Incubation n period period ranges ranges from from 2 to to 9 days in in A Rhinovirus infection
C Coxsackievirus infection
B Echovirus infection
D Poliovirus infection
35. Which of the following following is associated associated with the virulence virulence factor of Enteropathogenic Enteropathogenic E coli (EPEC) that causes diarrhea? A Verotoxin
C O antigen
B Hemolysin
D Heat-labile exotoxin (LT)
36. Which of the following statements statements is/are is/are correct about antiviral antiviral drugs? drugs? A Foscarnet is an HIV fusion inhibitor B Acyclovir is ineffective against cytomegalovirus
C Amantadine has no effect on Influenza A D Ribavirin is a protease inhibitor
37. A nucleoside analogue that that causes chain terminat termination ion during during DNA synthesis: synthesis: A Didanosine
Nevirapin inee C Nevirap
B Foscarnet
D Adefovir
38. Hydatidosis or hydatid hydatid cysts cysts may may result result from infection with: A Paragonimus westermani
C Echinococcus granulosus
B Fasciola hepatica
D Schistosoma mansoni
39. Which of the following cause about 60% 60% of cases of mucormycos mucormycosis? is? neoformans A Cryptococcus neoformans
C Rhizopus oryzae
Histoplasma capsulatum B Histoplasma
D Aspergillus fumigatus
40. Which of the following statements statements about Interferon is/are incorrect? A has antiviral action
C triggers synthesis of oligo(A) synthetase
B activates the initiation factor elF-2
D its synthesis is stimulated by double-stranded RNA 41. Hepatitis Hepatitis E virus virus belongs belongs to the the family/ family/genus genus:: A Caliciviridae
C Hepevirus
B Hepadnaviridae
D Hepatovirus
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MCQ-Series
Practice Test II
Microbiology
42. IFN-a IFN-a is deriv derived ed from from A antigen-stimulated T cells
C virus-infected fibroblasts
B macrophages and NK cells
virus-infected leukocytes D virus-infected
43. All of the following are directly transmi transmitted tted to humans by by arthropods except: A Rocky Mountain spotted fever
C Epidemic typhus
B Scrub typhus
D Q fever
44. The causativ causativee organism organism of Texas Texas cattle cattle fever fever A Bartonella
C Babesia
B Brucellae
D Borrelia
45. Which Which of the foll following owing is an "endobioti "endobiotics"? cs"? A Lactobacillus casei
C Benzoic acid
Nicotine ne B Nicoti
D Bile acids
46. Which of the following following chemicals chemicals is generally generally used for disinfection disinfection and sterilization? sterilization? A Peracetic acid
C Chlorhexidine
B Benzoic acid
D Phenol
47. Immune Immune reconstitution reconstitution inflamm inflammatory atory syndrome syndrome (IRIS) is seen in patients with with AIDS who are infected with______ when they are given HAART. A Cryptococcus
C Rhizopus
B Aspergillus
D Candida
48. Natural Natural reservo reservoir ir of Balantidi Balantidium um coli: coli: A Cat
C Dog
B Sheep
Pig D Pig
49. Which of the following is a major component of spores/endospores? spores/endospores? A Dipicolinic acid
C Muramic acid
B Diaminopimelic acid
Lipoteichoic acid D Lipoteichoic
50. Endogenous Endogenous infectio infection n is is caused caused by: A R. oryzae
C A. fumigatus
B P. boydii
D C. albicans
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MCQ-Series
Practice Test II
Microbiology
51. All of the followin following g are normal normal microb microbiota iota of the the vagina except: except: A Klebsiella spp.
C Bacteroides spp.
B Diphtheroids
D Clostridium spp.
52. Treponem Treponemaa pertenue pertenue is the the causativ causativee organism organism of A Syphilis
C Bejel
B Yaws
D Pinta
53. All of the following following are examples examples of Type IV delayed hypersensitivity hypersensitivity reactions reactions except: except: A Histoplasmosis
C Poison ivy
B Urticaria
D Contact dermatitis.
54. During DNA replication, proofreading proofreading the the chain for mistakes mistakes is primarily primarily the the function of of A RNA polymerase
C DNA polymerase I
B Ligase
D DNA polymerase III
55. Which of the following following organisms organisms is associated associated with hemolytic hemolytic uremic uremic syndrome syndrome (HUS)? A EnteroinvasiveE coli (EIEC)
C Enterohemorrhagic E coli (EHEC)
B EnterotoxigenicE coli (ETEC)
D EnteropathogenicE coli (EPEC)
56. The functio function n of enzyme enzyme Helicas Helicasee in DNA replicati replication: on: A Adding bases to the new DNA chain
C Unzipping the DNA helix
B Supercoiling
D Removing primer
57. The lethal lethal dose dose of abrin abrin (a toxic toxic lectin) lectin) in in mice mice is A <0.11µg/kg
C <0.1µg/kg
B >0.1µg/kg
D >0.11µg/kg
58. Naegler Naegleria ia belong belongss to: A Helminth
C Protozoa
B Bacteria
D Fungi
59. Type IV hyperse hypersensit nsitivit ivity y reacti reaction: on: A involves IgG and complement system
C is a type of cytotoxic hypersensitivity
B involves cytokines and T lymphocytes
D caused by antigen-antibody aggregates
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MCQ-Series
Practice Test II
Microbiology
60. The causativ causativee organism organism of Well Well's 's disease: disease: A Trypanosoma brucei
C Borrelia burgdorferi
B Leptospira interrogans
D Anisakis simplex
61. A severe variant of erythema erythema multiform multiformee that affects the the eyes and genitalia: A Kartagener's syndrome
C Young's syndrome
syndrome B Churg-Strauss syndrome
syndrome D Stevens-Johnson syndrome
62. For steril sterilizat ization ion purpose purposes, s, Arnold Arnold sterilize sterilizerr uses A Pressurized steam
C Fractional sterilization
B Hot air
D Ultraviolet light
63. The most sensitive method method for detection of rotavirus nucleic nucleic acid from from stool stool specimens: specimens: A DNA microarrays
C PCR
B Disk-diffusion method
D ELISA
64. The Siege Siege of Caffa involv involved ed a sorely sorely dreaded dreaded disease: disease: Which Which was it? A Epidemic typhus
C Plague
B Smallpox
D Typhoid
65. Drug of choice choice for for the treatm treatment ent of Erysip Erysipelas: elas: A Streptomycin
C Erythromycin
B Tetracycline
D Amphotericin B
66. The prime prime cause of acute hemorrh hemorrhagic agic conjunc conjunctivi tivitis tis:: A Rhinoviruses 87
C Enterovirus 70
B Enterovirus 72
D Echoviruses 22
67. The natu natural ral host host of Isos Isospor pora: a: A Cattle
C Cats
B Dogs
D Horses
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MCQ-Series
Practice Test II
Microbiology
68. Identify Identify the structur structuree given given below: below:
A Pyrimidine
C Purine
Nucleotid idee B Nucleot
Nucleoside ide D Nucleos
69. Which Which of the following following vaccines vaccines do not contai contain n live viruses? viruses? A Hepatitis B vaccine
C Varicella zoster vaccines
B Influenza vaccine
D MMR vaccine
70. Which Which of the foll following owing is a Sporo Sporozoa? zoa? A Leishmania
C Trichomonas
B Trypanosoma
D Toxoplasma
71. The causativ causativee organism organism of Sleepin Sleeping g sickness sickness is : A Trypanosoma cruzi
C Bartonella henselae
B Brucella melitensis
Trypanosoma brucei D Trypanosoma
72. Bacitraci Bacitracin n is highly highly toxic toxic to the A Kidney
C Bone marrow
B Liver
D Cochlear
73. Match the following following about about E coli-Associated Diarrheal Diseases with their their correct correct alternatives: A.
Enterotoxigenic E coli
A. produce ST-like toxin
B.
Ent Enteroh erohem emo orrha rrhag gic E col coli
B. col coloniza nizattion fact facto ors
C.
Enteropathogenic E coli
C. H antigen
D.
Enteroinvasive E coli
D. O157:H7 serotype
E.
Enteroaggregative E coli
E. nonlactose fermenters
74. Transplace Transplacental ntal or congeni congenital tal infecti infections ons does not not occur with: with: A Syphilis
C Rubella
B Yaws
D Cytomegalovirus
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MCQ-Series
Practice Test II
Microbiology
75. A mild form of typhus believed to be due to relapse relapse of an earlier earlier case of typhus: typhus: A Endemic typhus
C Relapsing fever
B Recrudescent typhus
D Scrub typhus
76. Which Which of the following following plays plays role role in induction induction of septic septic shock? shock? A Lipoteichoic acid
C Muramic acid
B Diaminopimelic acid
Dipicolinic acid D Dipicolinic
77. All of the following following methods methods are used to detect detect or quantify bacterial endotoxins (BET) except: A Gel-clot method
C Lysis-centrifugation method
B Turbidimetric kinetic method
D Chromogenic end point method
78. Which of the following is a "counterstain" "counterstain" used in Gram staining method? method? A Carbolfuchsin
C Acetone
B Safranin
D Crystal violet
79. Severe combined combined immunodeficiency immunodeficiency disease (SCID) (SCID) is characterized by: A lack of C3 complement component
C T cell depletion
B B cell depletion
D depletion of both B and T cells
80. Hand-footHand-foot-andand-mo mouth uth diseas diseasee is caused by A Enterovirus
C Echovirus
B Coxsackievirus
D Rhinovirus
81. A disease that occurs in humans due to eating eating uncooked uncooked fish (mullet): (mullet): A Gnathostomiasis
C Heterophyiasis
B Fasciolopsiasis
D Echinostomiasis
82. All of the the following following are are nucleoside nucleoside analogu analogues es except: except: A Indinavir
Nevirapin inee C Nevirap
B Vidarabine
D Lamivudine
83. Which of the following following stains is is used in staining staining specimen specimen for fungal forms? forms? A Potassium hydroxide
C Safranin
B India ink
D Carbolfuchsin
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MCQ-Series
Practice Test II
Microbiology
84. The pathogen most most likely likely to cause soft soft tissue tissue and skin infections infections transmi transmitted tted by human human bite: bite: A Eikenella corrodens
C Aeromonas hydrophila
B Erysipelothrix rhusiopathiae
phagocytophilum D Anaplasma phagocytophilum
85. Erythema Erythema nodosum could be a likely manifestation manifestation of of infection infection with: A Y enterocolitica
C G lamblia
B C jejuni
D C immitis
86. Dimorp Dimorphic hic fung fungii inclu includes des:: A Aspergillus fumigatus
neoformans C Cryptococcus neoformans
B Rhizopus oryzae
D Penicillium marneffei
87. Toxic Toxic shock shock syndr syndrom omee is caused caused by A S pyogenes
C S dysenteriae
B C perfringens
D S aureus
88. “Cold “Cold agglu aggluti tini nins” ns” test test A IgA
IgG C IgG
B IgD
IgM D IgM
89. Q feve feverr is is caus caused ed by: by: A Bartonella henselae
C Coxiella burnetii
B Ehrlichia chaffeensis
D Borrelia burgdorferi
90. The cause cause of relapsi relapsing ng fever fever in the the western western United United States: States: A Borrelia burgdorferi
C Borrelia hermsii
B Borrelia recurrentis
D Borrelia garinii
91. What determi determines nes the virulence virulence of Enterotoxigenic Enterotoxigenic E coli (ETEC) that causes diarrhea? A Verotoxin
C Hemolysin
B Heat-stable enterotoxin STa
D O antigen
92. Erythema Erythema nodosum is associated associated with all of the following diseases/conditions diseases/conditions except: except: A Herpes simplex virus infection
C Leprosy
B Cat-scratch disease
D Yersinia enterocolitica infection
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MCQ-Series
Practice Test II
Microbiology
93. All of the the following following are are flagellat flagellatee protozoa protozoa except: except: A Leishmania
C Trypanosoma
B Sarcocystis
D Histomonas
94. One of the following statements statements about diphtheria/diphtheri diphtheria/diphtheriaa toxin is incorrect: incorrect: A the active (A) domain posses enzymatic activity
C toxin is an endotoxin D toxin is part of a bacteriophage called lambda phage
B transmitted by airborn droplets 95. Incorrect Incorrect about Rhizopus Rhizopus oryzae: oryzae: A nonseptate hyphae
C not dimorphic
B septate hyphae
D conidia enclosed in sporangium
96. Which of the the following microorganis microorganisms ms is the the leading cause of asceptic asceptic (viral) meningiti meningitis? s? A Parvoviruses
C Togaviruses
B Caliciviruses
D Echoviruses
97. A cellular immunodeficiency immunodeficiency disease in which T cells cells fails to develop: A Ataxia-telangiectasia
C DiGeorge syndrome
B Bruton agammaglobulinemia
syndrome D Chediak-Higashi syndrome
98. The incubat incubation ion perio period d of Relapsin Relapsing g fever fever is: A 4-5 days
C 10-14 days
B 3-10 days
D 5-7 days
99. Match the following following E coli strains 'most commonl commonly' y' associated with their correct correct alternatives: A.
Ente Entero ropa path thog ogen enic ic E coli coli
A. hem hemolyt olytic ic urem uremic ic synd syndro rom me
B.
Ente Entero rottoxi oxigeni genicc E coli coli
B. dise diseas asee very very sim similar ilar to shig shigel elllosis osis
C.
Ente Entero rohe hem morrh orrhag agic ic E coli coli
C. food food-b -bor orne ne illn illnes esse sess in indu indust stri rial aliz ized ed countries
D.
Ente Entero roin inva vasi sive ve E coli coli
D. diar diarrh rhea ea in infa infant ntss in deve develo lopi ping ng coun countr trie iess
E.
Ent Enteroa eroag ggreg gregat atiive E col coli
E. travel aveler er’s ’s diarr arrhea hea
100. What is is the role role of DNA polymerase polymerase III III during during DNA replicati replication? on? A Repairing mismatches
C Removing primer
B Adding bases to the new DNA chain
D Synthesizing an RNA primer
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MCQ-Series
Practice Test II
Microbiology
Disclaimer: This question series is a mock test for practice. Students can undertake the exam under time settings. This mock test is designed to recap critical and essential facts related to Pre-clinical science domains. Questions are based on theoretical understanding of the topics which links to bedside clinical approach.
Please Please note: note: Multiple Choice Questions with inaccurate language or wrong choices may better be left left unanswer unanswered. ed. This This practi practice ce series series is is availab available le free free to downlo download, ad, and desi designe gned d for the the benefi benefitt of gradua graduate te and postpost-gra gradua duate te medi medical cal stude students nts.. Every attempt has been made to validate each and every question/answer. All remaining remaining errors are deeply regretted. Author will not be held responsible for any errors. Please consult the standard textbooks given in the reference section for any discrepancy. Reference Textbooks: 1. Medical Microbiology: Jawetz, Melnick & Adelberg's, 24th Edition, Lange McGraw-Hill publications publications 2. Microbiology: Microbiology: Prescott M. Lansing (Ed): Prescott- Harley- Klein, 5th Edition McGraw-Hill publications publications
Author Email:
[email protected]
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