ÍNDICE: INTRODUCCIÓN....................................................... OBJETIVOS............................................................... HIPÓTESIS................................................................ METODOLOGÍA........... METODOLOGÍA.................... .............................................. ..................................... RESULTADOS Y OBSERVACIONES......................... ANÁLISIS DE RESULT RESULTADOS................................... ADOS..................................... CONCLUSIONES.............. CONCLUSIONES....................... ......................................... ................................ ANEXOS.................................................................... ANEXOS.................................................................... REFERENCIAS.............. REFERENCIAS.......................................................... ............................................
INTRODUCCIÓN La posoo!"a #s $%a &a'a (# a )a&'a*oo!"a +$# s# #%*a&!a (# a (os,),*a*,-% (# )&'a*os s#!/% # p#so0 #(a(0 1 o&!a%,s'o (# pa*,#%2#. Es2a (,s*,p,%a 3a*#
%$ ap&o4,'a(o (# a*$#&(o *o% as ps#%2a*,o%#s )a&'a*5$2,*as a%6a(as #% # '#&*a(o (# os '#(,*a'#%2os0 1a +$# %o s# p$#(# 2o'a& a (os,s #4a*2a (# os ** **$ $os os poso poso-!, !,*o *os. s. Es $%a $%a (# as as *a&a *a&a*2 *2#& #&"s "s2,2,*a *ass 's 's ,'po ,'po&2 &2a% a%2# 2#ss 1 2&as* 2&as*#% #%(# (#%2 %2a a#s #s (# a )a&' )a&'a* a*o oo! o!"a "a 2#&ap 2#&ap5$ 5$2,2,*a *a (#7, (#7,(o (o a +$# +$# $% po&*# po&*#%2 %2a8 a8# # #9a%2# #9a%2# (# as )aas #% a )a&'a*o2#&ap,a )a&'a*o2#&ap,a s$2a% s$2a% (# a (os,),*a*,-% (os,),*a*,-% #&&-%#a (# os '#(,*a'#%2os ,%(,*a(os. :F,!$#&oa0 ;<<<= S# p$#(# (#),%,& a a (os,s *o'o a *a%2,(a( (# )&'a*o +$# s# (#7# a(',%,s2&a& a $%a p#&so%a pa&a o72#%#& $% #)#*2o (#2#&',%a(o. >s2a #s a (os,s 2#&ap5$2,*a o #)#*2,9a #)#*2,9a +$# #s2 #%2 a (os,s 2#&ap5$2,*a 2#&ap5$2,*a '"%,'a '"%,'a :a '#%o& (os,s +$# #s *apa6 (# p&o($*,& #)#*2o= 1 a (os,s 2#&ap5$2,*a '4,'a :'a1o& (os,s 2o#&a(a s,% +$# apa*a% #)#*2os 2-4,*os=. Las (os,s (# os )&'a*os #s2% *a*$a(as pa&a a*a%6a& os %,9##s pas'2,*os %#*#sa&,os pa&a +$# apa*a # #)#*2o s,% #!a& a %,9##s 2-4,*os. :A3$'a(a0 ?@@?= U%a (# as )o&'as 's $s$a#s pa&a a ps*&,p*,-% '5(,*a0 #s a *#2a '5(,*a. E% #a #a s# # s#a s#aa a a )a&' )a&'a* a*5$ 5$2,2,*o *o # '#(, '#(,*a *a'# '#%2 %2o o +$# +$# (#7# (#7# #4p#% #4p#%(# (#&. &. I!$a'#%2# *o%2,#%# as ,%s2&$**,o%#s +$# (#7# s#!$,& # #%)#&'o #% *$a%2o a a a(',%,s2&a*,-% (# )&'a*o. :A3$'a(a0 ?@@?=. Es *a2a *a2ao o!a !a(a (a 2a'7 2a'7,5 ,5% % *o'o *o'o $% (o*$ (o*$'# '#%2 %2o o #!a #!a00 (o%( (o%(# # $% p&o) p&o)#s #s,o ,o%a %a *apa* *apa*,2,2a( a(o o :'5( :'5(,* ,*os os00 MV0 MV0 o(o% o(o%22-o o!o !os0 s0 ps,+ ps,+$, $,a2 a2&as &as 1 pa&2# pa&2#&a &as= s= ps* ps*&, &,7# 7# '#(,*a'#%2os. Es ,'po&2a%2# *o%o*#& as pa&2#s +$# a *o'po%#% No'7 (# (# '5(, '5(,*o *o :,'p :,'ps so= o= 2. I%s2,2 I%s2,2$*, $*,-% -% +$# o2o&!o2o&!- # 2"2$o 2"2$o p&o)#s, p&o)#s,o%a o%a 1.No'7 :,'pso= 3. Esp#*,a,(a( :,'pso0 s, a 2,#%#= 4. C5($a p&o)#s,o%a ,'pso 5. Do',*,,o pa&2,*$a& 1 2#5)o%o :,'pso= 6. No. (# Fo,o :%o o7,!a2o&,o= 7. No'7 (# (# pa* pa*,#%2 ,#%2# # 8. F#*3 F#*3a a (# ps* s*&, &,p* p*,,-% 9. F,&' F,&'a a a$2a$2-!& !&a) a)a a (# (# '5(, '5(,*o *o 10. D#%o',%a*,-% D#%o',%a*,-% (,s2,%2,9a (,s2,%2,9a 11. D#%o',%a*,-% D#%o',%a*,-% !#%5&,*a !#%5&,*a 12. Fo&'a )a&'a*5$2, )a&'a*5$2,*a *a 13. Ps#%2a*,-% 14. Dos,),*a*,-% 15. D$&a*,-% (# 2&a2a',#%2o. E#'#%2os a(,*,o%a#s +$# p$#(# *o%2#%#& $%a *#2a '5(,*a : 16= I'ps,-% (,a!%-s2,*a :I.D.=0 )*$#%*,a sp,&a2o&,a :F.R.=0 2#%s,-% a&2#&,a :T.A.=0 )*$#%*,a *a&(,a*a :F.C.=0 :F.C.=0 p#so0 2#'p#&a2$&a *o&po&a :TEMP.=0 :TEMP.=0 2aa o #s2a2$&a o a2$&a0 #(a(0 a#&!,as0 1 *-(,!o (# 7a&&as.
OBJETIVOS O78#2,9o !#%#&a
2
ap&o4,'a(o (# a*$#&(o *o% as ps#%2a*,o%#s )a&'a*5$2,*as a%6a(as #% # '#&*a(o (# os '#(,*a'#%2os0 1a +$# %o s# p$#(# 2o'a& a (os,s #4a*2a (# os ** **$ $os os poso poso-!, !,*o *os. s. Es $%a $%a (# as as *a&a *a&a*2 *2#& #&"s "s2,2,*a *ass 's 's ,'po ,'po&2 &2a% a%2# 2#ss 1 2&as* 2&as*#% #%(# (#%2 %2a a#s #s (# a )a&' )a&'a* a*o oo! o!"a "a 2#&ap 2#&ap5$ 5$2,2,*a *a (#7, (#7,(o (o a +$# +$# $% po&*# po&*#%2 %2a8 a8# # #9a%2# #9a%2# (# as )aas #% a )a&'a*o2#&ap,a )a&'a*o2#&ap,a s$2a% s$2a% (# a (os,),*a*,-% (os,),*a*,-% #&&-%#a (# os '#(,*a'#%2os ,%(,*a(os. :F,!$#&oa0 ;<<<= S# p$#(# (#),%,& a a (os,s *o'o a *a%2,(a( (# )&'a*o +$# s# (#7# a(',%,s2&a& a $%a p#&so%a pa&a o72#%#& $% #)#*2o (#2#&',%a(o. >s2a #s a (os,s 2#&ap5$2,*a o #)#*2,9a #)#*2,9a +$# #s2 #%2 a (os,s 2#&ap5$2,*a 2#&ap5$2,*a '"%,'a '"%,'a :a '#%o& (os,s +$# #s *apa6 (# p&o($*,& #)#*2o= 1 a (os,s 2#&ap5$2,*a '4,'a :'a1o& (os,s 2o#&a(a s,% +$# apa*a% #)#*2os 2-4,*os=. Las (os,s (# os )&'a*os #s2% *a*$a(as pa&a a*a%6a& os %,9##s pas'2,*os %#*#sa&,os pa&a +$# apa*a # #)#*2o s,% #!a& a %,9##s 2-4,*os. :A3$'a(a0 ?@@?= U%a (# as )o&'as 's $s$a#s pa&a a ps*&,p*,-% '5(,*a0 #s a *#2a '5(,*a. E% #a #a s# # s#a s#aa a a )a&' )a&'a* a*5$ 5$2,2,*o *o # '#(, '#(,*a *a'# '#%2 %2o o +$# +$# (#7# (#7# #4p#% #4p#%(# (#&. &. I!$a'#%2# *o%2,#%# as ,%s2&$**,o%#s +$# (#7# s#!$,& # #%)#&'o #% *$a%2o a a a(',%,s2&a*,-% (# )&'a*o. :A3$'a(a0 ?@@?=. Es *a2a *a2ao o!a !a(a (a 2a'7 2a'7,5 ,5% % *o'o *o'o $% (o*$ (o*$'# '#%2 %2o o #!a #!a00 (o%( (o%(# # $% p&o) p&o)#s #s,o ,o%a %a *apa* *apa*,2,2a( a(o o :'5( :'5(,* ,*os os00 MV0 MV0 o(o% o(o%22-o o!o !os0 s0 ps,+ ps,+$, $,a2 a2&as &as 1 pa&2# pa&2#&a &as= s= ps* ps*&, &,7# 7# '#(,*a'#%2os. Es ,'po&2a%2# *o%o*#& as pa&2#s +$# a *o'po%#% No'7 (# (# '5(, '5(,*o *o :,'p :,'ps so= o= 2. I%s2,2 I%s2,2$*, $*,-% -% +$# o2o&!o2o&!- # 2"2$o 2"2$o p&o)#s, p&o)#s,o%a o%a 1.No'7 :,'pso= 3. Esp#*,a,(a( :,'pso0 s, a 2,#%#= 4. C5($a p&o)#s,o%a ,'pso 5. Do',*,,o pa&2,*$a& 1 2#5)o%o :,'pso= 6. No. (# Fo,o :%o o7,!a2o&,o= 7. No'7 (# (# pa* pa*,#%2 ,#%2# # 8. F#*3 F#*3a a (# ps* s*&, &,p* p*,,-% 9. F,&' F,&'a a a$2a$2-!& !&a) a)a a (# (# '5(, '5(,*o *o 10. D#%o',%a*,-% D#%o',%a*,-% (,s2,%2,9a (,s2,%2,9a 11. D#%o',%a*,-% D#%o',%a*,-% !#%5&,*a !#%5&,*a 12. Fo&'a )a&'a*5$2, )a&'a*5$2,*a *a 13. Ps#%2a*,-% 14. Dos,),*a*,-% 15. D$&a*,-% (# 2&a2a',#%2o. E#'#%2os a(,*,o%a#s +$# p$#(# *o%2#%#& $%a *#2a '5(,*a : 16= I'ps,-% (,a!%-s2,*a :I.D.=0 )*$#%*,a sp,&a2o&,a :F.R.=0 2#%s,-% a&2#&,a :T.A.=0 )*$#%*,a *a&(,a*a :F.C.=0 :F.C.=0 p#so0 2#'p#&a2$&a *o&po&a :TEMP.=0 :TEMP.=0 2aa o #s2a2$&a o a2$&a0 #(a(0 a#&!,as0 1 *-(,!o (# 7a&&as.
OBJETIVOS O78#2,9o !#%#&a
2
Co%o*#& Co%o*#& # #%!$a8# #%!$a8# 7s,*o )a&'a*o-!,*o0 )a&'a*o-!,*o0 ap,*a& **$os 'a2#'2,*os 'a2#'2,*os 1 ,sa& *#2as '5(,*as '#(,a%2# # *o%o*,',#%2o (# 25&',%os a*,o%a(os *o% # a0 pa&a ,%2#&pa& a posoo!"a. O78#2,9os #sp#*"),*os ;. Co%o* Co%o*#& #& # #%! #%!$a $a8# 8# 7s, 7s,*o *o )a&' )a&'a*o a*o-!, !,*o *o '#(,a '#(,a%2 %2# # a (,s* (,s*$s $s,,-% % (# as as (#),%,*,o%#s p ,a'#%2# ,%9#s2,!a(as0 pa&a ,(#%2,),*a& # pa%2#a',#%2o (# *a(a $%o (# os p&o7#'as. ?. Ap,*a& Ap,*a& **$os **$os 'a2#'2,*o 'a2#'2,*oss pa&a a *o&*2a *o&*2a (os,),*a (os,),*a*,-% *,-% (# os os )&'a*os )&'a*os '#(, '#(,a% a%2# 2# a so so$ $*, *,-% -% (# p&o7 p&o7# #'a 'ass as,! as,!%a %a(o (oss po& po& # p&o) p&o)#s #so& o& (# a7o&a2o&,o pa&a a a(',%,s2&a*,-% &a*,o%a (# #s2os. . R#9,sa R#9,sa&& $%a *#2a '5(,*a '5(,*a po& '#(,o '#(,o (# a ,(#%2, ,(#%2,),* ),*a*, a*,-% -% (# as pa&2#s (# 5s2a0 pa&a a%a,6a& os (a2os poso-!,*os ps*&,2os po& # '5(,*o.
HIPÓTESIS A *o%o*#& 1 *o'p%(#& # #%!$a8# 7s,*o )a&'a*o-!,*o 8$%2o *o% *o%o* *o%o*,' ,',# ,#%2 %2os os 'a2#' 'a2#'2 2,* ,*os os p , p ,os0 os0 s# (,sp (,spo% o%(& (& (# a *apa *apa*, *,(a (a( ( pa&a pa&a a so$*,-% *o&*2a (# p&o7#'as poso-!,*os 1 a #9a$a*,-% (# ps*&,p*,o%#s #% *#2as '5(,*as.
METODOLOÍ!
3
RESULT!DOS # OBSERV!CIONES I. S$%&$ '$ (%)*+$,- ;. C$%2os ! (# *o&$&o (# so(,o *o%2,#%#% @@ ',,,2&os (# as s,!$,#%2#s so$*,o%#s
-/ 5 5=
5 gNaCl 100 mL disolución
5 g NaCl 100 mL
∗500 mL =25 g NaCl
4
1000 µg 1 mg
25 g NaCl
∗1000 mg =25000000 µg
1g
*/ 0.5 0.5 =
0.5 g NaCl 100 mL disolución
0.5 g NaCl 100 mL
∗500 mL= 2.5 gNaCl
1000 µg 2.5 g NaCl
1 mg
∗1000 mg =2500000 µg
1g
/ 0.05 0.05 =
0.05 g NaCl 100 mL disolución
0.05 g NaCl 100 mL
∗500 mL=0.25 gNaCl 1000 µg
0.25 g NaCl
1 mg
∗1000 mg
1g
=250000 µg
'/ 0.005 0.005 =
0.005 g NaCl 100 mL disolución
0.005 g NaCl 100 mL
∗500 mL=0.025 gNaCl
1000 µg 0.025 g NaCl
1 mg
∗1000 mg
1g
=25000 µg
5
?. E 3,(&a2o (# *o&a 9,#%# #% so$*,-% (# ; ',,,2&os +$# *o%2,#%# ; !&a'o (# )&'a*o. A +$5 po&*#%2a8# #s2 (,*3a so$*,-% 1 g de farmaco 15 mL
∗100 mL =6.666
. E '#(,*a'#%2o G,%o Da2a&,% K *o%2,#%# N,2&a2o (# ',*o%a6o ;@@'! E4*,p,#%2# *.7.p. ?'! A +$5 po&*#%2a8# s# #%*$#%2&a # p&,%*,p,o a*2,9o Co%2#%,(o 2o2a (# '#(,*a'#%2o
|
100 mg
100 375 mg
|=
¿ 100 mg + 275 mg =375 mg
26.66
. E% # '#&*a(o s# #%*$#%2&a% a'po#2as (# Co&3,(&a2o (# a(%a,%a *$1a *o%*#%2&a*,-% #s (# ; '!'L C$ #s # po&*#%2a8# (# (,*3a so$*,-% 1 mg 1 mL
∗1 g
1000 mg
=0.1
. C$%2os '! (# S$)a2,a6o s-(,*o s# +$,#% pa&a ppa&a& @'L (# $%a so$*,-% a ? 2g 100 mL
∗1000 g
1g
∗50 mL=1000 mg de Sulfatiazolsódico
6
Q. R#+$,#s ppa&a& ; ,2&o (# 3,(&-4,(o (# so(,o @.; N. C$%2os ! (# 3,(&-4,(o (# so(,o *o% p$a (# << %#*#s,2as pa&a ppa&a&a NaOH ∗0.1 eq ∗1 mol 1 L ∗ 40 gRPdeNaOH 1 eq ∗100 g RA 1 molNaOH =4.04 g 1 L de 99 g RP
. E D#),%o4,a2o #s $% )&'a*o a%2,(,a&,*o. La (os,s +$# s# a(',%,s2&a #% %,os #s (# @.@ '!!. E ppa&a(o *o'#&*,a 9,#%# a $%a *o%*#%2&a*,-% (# @.@. C$%2os 'L (# #s2# s# # 2,#%#% +$# a(',%,s2&a& a $% %,o +$# p#sa ?? ! 0.05 =
0.05 g
100 mL disolución
0.05 mg 1 Kg
∗32.2 Kg=1.61 mg
100 mL 0.05 g
∗1 g
1000 mg
∗1.61 mg=3.22 mL
. Pa&a (#2#&',%a& $%a *$&9a (os,ssp$#s2a a a a(%a,%a s# +$,# ppa&a& as s,!$,#%2#s so$*,o%#s @@0 ;@@0 ;@0 0;0 @.0 @.;0 @.@ 1 @.@; ! #% ?'L s, # '#(,*a'#%2o 2,#%# $%a ps#%2a*,-% #% so$*,-%0 a *$a *o%2,#%# ;@@ '! (# *o&3,(&a2o (# a(%a,%a #% ;@@'L0 C$#s so% os **$os pa&a ppa&a& ? 'L (# *a(a $%a (# as so$*,o%#s (# a(%a,%a As$',#%(o +$# pa&a *a(a so$*,-% +$# s# +$,# ppa&a& s# s,!$# # ',s'o p&o*#(,',#%2o0 s# 'os2&a& a *o%2,%$a*,-% /%,*a'#%2# # 2&a2a',#%2o 'a2#'2,*o (# $%a (# #as 1 (# os (#'s soo s$ s$2a(o. 300 μg F
150 μg F
2 mLdis
mL dis
=
7
|
25 mLdis
|=
1 mg F
mLdis
1000 μg F
100 mg F 100 mL dis
|
3.75 mg F
||
150 μg F
=
3.75 mg F
1 mg F 1 mLdis
1 mLdis 1 mg F
|=
3.75 mL dis
So. a ppa&a& : μg F ¿ mLdis
Vo$'#% %#*#sa&,o (# a ps#%2a*,-% :'L=
150
3.75
50
1.25
15
0.3750
5
0.1250
1.5
0.0375
0.5
0.0125
0.15
0.0037
0.05
0.0012
0.015
0.0003
0.005
0.0001
<. D#sp$5s (# $%a ,%2#&9#%*,-% +$,&/&!,*a s# (#s#a a(',%,s2&a& # '#(,*a'#%2o P#%p&o*,,%aK a $%a &a2a. La (os,s #s (# @.;'L (# '#(,*a'#%2o ppa&a(o 1 a )o&'$a*,-% #s a s,!$,#%2# P#%,*,,%a G s-(,*a .............................................. ;@@0@@@ UI 8
P#%,*,,%a G p&o*a"%,*a ........................................ @@0@@@ UI A!$a I%1#*2a7# .................................................... ?'L
E&-+$&- ; '! p#%,*,,%a G s-(,*a ;QQ UI ; '! p#%,*,,%a G p&o*a"%,*a ;@@< UI -/ C) , $ +$ $ -',&&%-') '$ -'- - '$ +- ($&&+&- - +%-- 100,000 ! Penicilina "s
59.98 mg 2 mL
1667 !
=59.98 mg
∗0.1 mL =2.99 mg
300,000 ! Penicilina "#
297.32 mg 2 mL
1 mg
1 mg
=297.32 mg
1009 !
∗0.1 mL=14.86 mg
*/ ! ; ()%$-<$ $ $$%- +) ') &() '$ ($&&+&- G s-(,*a <.<'! ;@@ ?.<<'! R 4.98
G P&o*,%,*a ?<.?'! ;@@ ?.<<'! R= 4.99
;@.S# 2,#%# $% pa*,#%2# *o% p&o7#'as (# 3,p#&2#%s,-% 1 # '5(,*o (#*,(# a(',%,s2&a&# # '#(,*a'#%2o A(o'#2K0 # *$a 2,#%# *o'o p&,%*,p,o a*2,9o a '#2,(opa. :a%2,3,p#&2#%s,9o=. Es2# (#7# s#& a(',%,s2&a(o (# a s,!$,#%2# 'a%#&a ; 2a7#2a (,a&,a :a 2a7#2a *o%2,#%# ?@ '! (# '#2,(opa=0 pa&a $%a p#&so%a +$# p#sa Q !.
-/ >; ')& ()% '?- $ +$ $ -',&&%-') -+ (-&$$
|
1 $g
⟹
|=
250 mg F 67 $g
3.73 mg F
3.73 mg / $g / d
9
*/ >; -&'-' '$ @%,-) $ , $ +$ $ -',&&%-') -+ (-&$$ $ ($%&)') '$ 48 A)%-
|
48 %
|=
250 mg F 24 %
500 mg F
;;. E% # '#&*a(o #4,s2# $% '#(,*a'#%2o a'a(o A77o*,2&oK0 # *$a p$#(# %#$2&a,6a& # #4*#so (# a*,(#6 #% # #s2-'a!o. Es2# '#(,*a'#%2o 2,#%# a s,!$,#%2# )o&'$a*,-% C,2&a2o s-(,*o...@.<! B,*a&7o%a2o (# s-(,*o...;.?Q! A*,(o 2a&2&,*o.....;.;Q! A*,(o *"2&,*o.;.@!
-/ C) A- '$ -'- ) '$ $) &%$'&$$ 1000 mg
C,2&a2o s-(,*o
0.945 g
1g
∗1000 µg
1000 mg
B,*a&7o%a2o (# s-(,*o
1.264 g
1g
1g
1.073 g
1g
=1264000 µg
∗1000 µg
1 mg
1000 mg
Á*,(o *"2&,*o
∗1000 µg
1 mg
1000 mg
Á*,(o 2a&2&,*o 1.316 g
=945000 µg
1 mg
=1316000 µg
∗1000 µg
1 mg
=1073000 µg
*/ ! ; ()%$-<$ $ $$%- -'- ) '$ $++) 458000100
10
945000
C,2&a2o s-(,*o
Á*,(o *"2&,*o
100
1264000
B,*a&7o%a2o (# s-(,*o
1316000
Á*,(o 2a&2&,*o
µg∗458000 µg
1073000
=20.55
µg∗458000 µg 100
µg∗458000 µg 100
µg∗458000 µg 100
=27.4902
=28.6211
=23.3362
;?.R#+$,#s ppa&a& $%a so$*,-% sa,%a ),s,o-!,*a :Co&$&o (# so(,o a @.< =
-/ C) , %$&$%$ (-%- (%$(-%-% 1 +&%) '$ )+& 1000 mLdis
|
0.9 g F
100 mL dis
|
|=
1000 mg F 1 g F
9000 mg F
*/ -) $$&- (-%- (%$(-%-% 100 ,+ 100 mLdis
|
0.9 g F
100 mL dis
|
|
|=
1000 mg F 1000 μg F 1 g F
1 mg F
900000 μg F
;.U% pa*,#%2# ps#%2a ,%s$),*,#%*,a %a *&-%,*a0 pa&a #o s# # 2,#%# +$# a(',%,s2&a& F$&os#',(a :(,$&52,*o=0 *$1a (os,s #s (# @@ !! (# p#so *a(a 3o&as
-/ >; -&'-' $ +$ &$$ $ -',&&%-% -'- 12 A)%- - $$ (-&$$ & ($- 60 F
|
60 $g
|
12 %
|=
800 μg F
$g
|=
48000 μg F 8%
48000 μg F
72000 μg F
11
*/ ! ) $&-+$ $- -&'-'G $ -*+$-G s, a ps#%2a*,-% (# $%a 2a7#2a (# '#(,*a'#%2o #s a s,!$,#%2# F$&os#',(a.....?@ '! E4*,p,#%2# *. 7. p...;@'!
|
20 mg F
|=
1000 μg F 1 mg F
|
72000 mg F
20000 μg F
1 &a'leta
|=
20000 mg F
3.6 &a'letas
;.Pa&a $% #4p#&,'#%2o )a&'a*o-!,*o s# +$,# a(',%,s2&a& a &a2as W,s2a& 'a*3o 3,(&o*o&2,so%a po& 9"a ,%2&ap#&,2o%#a. Pa&a #o a (os,s (# #s2# )&'a*o #s (# @.? !! (# p#so. S, a so$*,-% #s2 a ?0 C$%2os ',,,2&os s# #s (#7# a(',%,s2&a& a as &a2as0 s, os p#sos (# #s2as so% ?@@0?;@0 ?@0 @@ 1 ;@ !&a'os @.?/:@.?=:;@@ /?= 2 @.?/:@.?=:;@@ /?= 2.5 @.?/:@.?=:;@@ /?= 2.8 @.?/:@.=:;@@ /?= 3 @.?/:@.;=:;@@ /?= 3.1
;.Ca*$a os ',,!&a'os (# D#42&osa %#*#sa&,os pa&a ppa&a&
-/ 200 ,+ '$ - )+& -)- - )$%-& $- '$ 0.3 ,,+. ?@@@. /60
*/ 100 ,+ '$ - )+& -)- '$ $$ -+ 10 . 12
|
100 mL
|
10 gde( 1000 mg de( 100 mL
1 g de(
|=
10000 mg de(
;Q.U% )&as*o 9,a *o%2,#%# @.;! (# $% )&'a*o ZA[ (,s$#2o #% ;@ 'L (# a!$a 7,o(#s2,a(a.
-/ >; )+,$ '$ $- )+& $ $$-%&) -',&&%-% - (-&$$ '$ 15 F '$ ($)G (-%- $ $$ %$&*- 30 , '$ (%&&(&) -&) 0.1 g A 10 mL dis
|
=
0.01 g A
mLdis
0.1 g A 1000 mg A
mL dis
30 mg A
|
1g A
|
=10 mg A dis mL
|
mL dis =3 mLdis 10 mg A
*/ C+ $ +- ')& $ $ $ +$ $ '-') - $$ (-&$$G -') $ +$ -',&&%- 30 , '$ $$ @%,-)
|
|=
30 mg A 15 $g
2 mg / $g
;.U% pa*,#%2# (,a752,*o *$1o p#so #s (# Q !0 +$,# a a(',%,s2&a*,-% (,a&,a (# ,%s$,%a a (os,s (# @.? U.I. ! (# p#so :9"a s$7*$2%#a=. Sa7,#%(o +$# os )&as*os 'p$as *o%2,#%#% ;@@ U.I. 'L :? U.I.'!= *a*$a
-/ L- &'-'$ '$ &+&- $ '$*$ %$&*&% $+ (-&$$ '&-%&-,$$. @.? UI ; ! Q !
R= 16.25 UI 13
*/ +) , '$ &+&- $ $+ (-&$$ %$&*$ ()% '?-. ? UI ;'! ;Q.? UI
R= 0.68 , / $+ )+,$ '$ +- )+& $ $+ (-&$$ %$&*$ '&-%&-,$$. ;@@ UI ;'L ;Q.? UI
R= 0.1625,L ;.La Ca&7a'a*#p,%a0 )&'a*o /2, #% # 2&a2a',#%2o (# !&a% 'a #p,5p2,*o0 (#7# a(',%,s2&as# a $% pa*,#%2# (# @ ! (# p#so. La (os,s #s (# ?@ '!! 1 a ps#%2a*,-% )a&'a*5$2,*a so% 2a7#2as (# @.? ! (#2#&',%a
-/ E+ ,$%) '$ -*+$- $ '$*$ $% -',&&%-'- '&-%&-,$$.
|
50 $g
0.2 g
|
|=
1000 mg
|=
200 mg
20 mg F
$g
1000 mg 1g
|
1000 0 g
1 ta'leta 200 mg
|=
5 ta'letas
*/ S& $+ ,$'&-,$) $ -',&&%- $ ') ),- -+ '?-G C- -*+$- A- $ '-% $ -'- )-& 5 ta'letas 2 tomas
=2.5 ta'leta s / toma
;<.U% )&as*o 'p$a *o%2,#%# $%a so$*,-% )o&'a(a po& @.! (# $% )&'a*o ZX[ 1 'L (# (,so9#%2# \$5 9o$'#% (# #s2a so$*,-% #s %#*#sa&,o a(',%,s2&a& a $% pa*,#%2# pa&a +$# #s2# *,7a ;@@ '! (# )&'a*o
14
|
|=
0.5 g F 1000 mg F 5 mL dis
|
100 mg F
1 g F
100 mg F
|
mLdis =1 mLdis 100 mg F
[email protected]% )&as*o 'p$a *o%2,#%# ?0 @@@0@@@ U.I. (# P#%,*,,%a G s-(,*a #% ?'L
-/ C) ,L '$ '&+$$ $$%&+&-') $ %$&$%$ (-%- (%$(-%-% )+& '$ 250G000 U.I.,L
[
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2 mL 2,000,000 !
]=
0.25 mL
*/ S-*&$') $ (-&$$ '$*$ %$&*&% 500G000 UI -'- 8 A)%- K?&%-,+-%/G ; )+,$ '$ +- )+& -$%&)% $ $$-%&) -',&&%-%+$ $ '?- 500,000 ! (
24 %rs 8 %rs
)
250,000 !
=6 mL
1 mL
?;.S# (,spo%# (# $%a so$*,-% (# a*o3o #% a!$a a @. \$5 9o$'#% (# #s2a so$*,-% s# %#*#s,2a pa&a ppa&a& ;@@@'L (# so$*,-% (# a*o3o a ? 80 g F 100 mL dis
25 g F 100 mL dis
=
=
1000 mLdis
|
250 g F
|
0.8 g F
mLdis 0.25 g F
mLdis
|=
0.25 g F
mLdis
250 g F
|
mLdis =312.5 mLdis 0.8 g F
15
??.La (os,s0 *o'o 3,p%-2,*o0 (# P#%2o7a&7,2a pa&a as &a2as #s (# @ '!! (# p#so. S# %#*#s,2a a(',%,s2&a& #s2as (os,s a a%,'a#s (# os s,!$,#%2#s p#sos ?@0 @@0;? 1 ?@@! s,% #'7a&!o0 a ps#%2a*,-% #s (# Q '!'L. \$5 a"*$o2a 2o'a&"as pa&a po(#& a(',%,s2&a& a (os,s a(#*$a(a a *a(a $%a (# as &a2as #% @. 'L o '#%os0 s, ppa&as ;@ 'L (# so$*,-% +$#&,(a 7.5
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?@@ :@/;@@@=Q.@
mg∗1 mL =0.11 mL 63 mg
mg∗1 mL = 0.142mL 63 mg
3.96
6.0
mg∗1 mL = 0.06mL 63 mg
mg ∗1 mL = 0.09mL 63 mg
?.E '#(,*a'#%2o T#'p&a *o%2,#%# #% *a(a ;@@ 'L Pa&a*#2a'o.... ;@! A*o3o #2",*o;@ 'L V#3"*$o *.7.p...;@@ 'L
-/ L- (%$$-& $ @%-) )$%) ) 20 ,L '$ )+&G >; -&'-' '$ (-%-$-,)+ A-*% $ $-
|
20 mLdis
10 gPar
|=
100 mLdis
2 g Par
*/ S& +- ')& (-%- &@-$ $ '$ 6 )- ()% -'- 5 F '$ ($)G >; -&'-' '$ (-%-$-,)+ $ +$ -(+&- - &) '$ 10 F '$ ($) $ '?-
|
10 $g
6 gotas 5 $g
|=
12 gotas
16
/ S& +- ')& $ -',&&%-'- -'- 8 A)%- $+ %--,&$) &$$ '%-& '$ 3 '?-G >; -&'-' $ +$ -',&&% $ )-+ '%-$ $$ &$,()
|
72 %
12 gotas 8%
|=
108 gotas
?.A $% ,%)a%2# (# '#s#s (# #(a( # ps*&,7,#&o% A*#2a',%o)#% #% so$*,-% ($&a%2# 2s ("as0 a (os,s )$# (# Q !o2as *a(a 3o&as. B$s*a& os (a2os (# a ps#%2a*,-% *o'#&*,a (# #s2# )&'a*o 1 (#*,& +$# *a%2,(a( s# # a(',%,s2&o #% '! a ),%a,6a& # 2&a2a',#%2o. ALPHARMA0 Pa&a*#2a'o Go2as0 ;@'!' 3 dias|
| |
24 %rs 6 gotas 1 dia
8 %rs
1 mL
|
10 mg
20 gotas 1 mL
=27 mg
?.S# (#s#a a(',%,s2&a& D,1o(o3,(&o4,+$,%o#,%a a $% pa*,#%2# (# ; ! (# p#so. S, a (os,s *o'#%(a(a #s (# '!! (# p#so po& ("a
-/ I'&$ + $ +- -&'-' ()% '?- '$ @%,-)G %$$%&'- (-%- +- (-&$$.
|
18 $g
|=
35 mg F
$g
630 mg F
*/ S& +- (%$$-& $ '$ 210 ,5 ,L &'&$ - ; )$%-& $ $$%- '&A) @%,-) $ ()%$-<$.
|
210 mg F
1 g F
|
5 mL dis 1000 mg F
( 100 mL=4.20
/ D&- -) ,L -+ '?- %$&$%$ +- (-&$$ (-%- *%&% +- ')&. 210 mg F 5 mL dis
= 42 mg F / mLdis
|
630 mg F
|
mL dis = 15 mL 42 mg F
17
?Q.S# ap,*a&% a $% pa*,#%2#0 (# ;? ! (# p#so0 Q 2o'as (# '#(,a *$*3a&a(,2a (# A*#2a',%o)5%0 ($&a%2# # ("a0 a ps#%2a*,-% (# (,*3o )&'a*o 2,#%# $%a *o%*#%2&a*,-% (# '! 'L. S, $%a *$*3a&a(,2a #+$,9a# a 'L (# 8a&a7#0 ,%(,+$#
-/ C) , ()% ),-'- $ $ (%$%&*&$') 75 mg F 5 mL dis
=15 mg F / mLdis
0.5 cuc%aradas
2.5 mLdis
|
|
5 mLdis 1 cuc%arada
|=
15 mg F
mL dis
|=
2.5 mLdis (toma
37.5 mg F
*/ >; ')& ()% ),- $ , '$ ($) $ $ &'&-')
|
1 $g
|=
37.5 mg F 12 $g
3.125 mg / $g / toma
/ C) , ()% '?- $ +$ -',&&%- 37.5 mg F
( 6 tomas =225 mg
?.La ps#%2a*,-% )a&'a*5$2,*a (# P#%2o7a&7,2a s-(,*o #s (# Q. !;@@ 'L (# '#(,*a'#%2o s, +$,#s ppa&a& (os so$*,o%#s0 $%a (# '!'L 1 o2&a (# <'!'L
-/ C) ,L '$ ,$'&-,$) &+&-%?- (-%- (%$(-%-% 50,L '$ -'- '$ +- )+&)$ %$$%&'- 6300 mg F 100 mL dis
|
5 mg
=
63 mg F
mL dis
|
mLdis =0.0794 mL ( 50 mL=3.96 mL 63 mg F
18
|
9 mg
|
mL dis = 0.1429 mL ( 50 mL=7.14 mL 63 mg F
*/ S& +- )+& '$ 5,,L $ &+&-% (-%- -',&&%-% +- &&$$ ')&: 25G 33G 50G 66 80 , '$ ($)G >; )+,$ -',&&%-%?- - %-)$ -+*&) ,-A) '$ 30 '$ ($)
| |= 25 mg
0.03 $g
$g
|
0.75 mg
0.75 mg
|
mL dis =0.15 mL 5 mg
→@.;< 'L @→@.@ 'L QQ→@.
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|
0.03 $g
|
3 mg
100 mg
$g
|=
3 mg
|
mL dis =0.33 mL 9 mg
;?→@.; 'L ;@→@. 'L ;→@. 'L ?@@→@.QQ 'L
19
?.La (os,s (# Wa&)a&,%a #s (# @.?; '!! (# p#so :9"a o&a=. E Co$'a("% #s $% '#(,*a'#%2o *o% a s,!$,#%2# )o&'$a*,-% ; 2a7#2a *o%2,#%# Wa&)a&,%a s-(,*a.. '! E4*,p,#%2#...?! S# +$,# a(',%,s2&a& Wa&)a&,%a a 2s a%,'a#s (# a7o&a2o&,o *o% os s,!$,#%2#s p#sos @0 @@ 1 @ !
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R= 4.2 */ I'&- +- -&'-' $ $ +$ -',&&%-%?- -'- -&,-+. 450 g|
300 g|
350 g|
1 $g
|
0.21 mg
|
0.21 mg
|
0.21 mg
1000 g
1 $g 1000 g
1 $g 1000 g
1 $g
1 $g
1 $g
|=
0.0945 mg
|=
0.063 mg
|=
0.0735 mg
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1 mL 0.2 mg
|=
se disuel)euna ta'letaen 25 mL dedisolución
20
?<.E Pa2#*2o& NFK #s $% a%2,*o%*#p2,9o0 *$1a )o&'$a*,-% #s a s,!$,#%2# ; 8#&,%!a *o%2,#%# A*#2o)5%,(o (# (,3,(&o4,p&o!#s2#&o%a '! E%a%2a2o (# #s2&a(,o... '! V#3"*$o *.7.p....; 'L
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5 mg 60 $g
=¿ ;.?'!! (# A*#2o)#%,(o (# (,3,(&o4,p&o!#s2#&o%a
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*/ >; -&'-' '$*$ '$ -',&&%-%$ - %-- &-% A$,*%- -'+- $ ($-: 280G312.5G 276.9 300 280 g|
1 $g 1000 g
312.5 g|
276.9 g|
300 g|
|
1 $g
1 $g 1000 g
1 $g 1000 g
1 $g 1000 g
|
| |
1.25 mg 1 mL
75 mg
|
=4.67 ( 10−3 mL
|
1.25 mg 1 mL
|
1.25 mg 1 mL
1 $g
|
1 $g
|
|=
75 mg
1.25 mg 1 mL 1 $g
|
75 mg
75 mg
=5.2 ( 10−3 mL
−3
4.53 ( 10
mL
|
=5 ( 10−3 mL
21
/ >; '&+& A-%?- (-%- -',&&%-% - -'- %-- +- -&'-' $$-%&- $ )+,$ ,$) ) &-+ - 0.4,LG (%$(-%-') 25,L '$ +- )+& −3
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|
=se disuel)e una ,eringa en 80 mLdedisolucion
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22
7= R#*#2a (# ,%s2,2$*,-% p/7,*a. No'7 (# '5(,*o0 C5($a p&o)#s,o%a0 Do',*,,o pa&2,*$a&. No'7 (# pa*,#%2#0 )#*3a (# ps*&,p*,-%. D#%o',%a*,-% (,s2,%2,9a0 (#%o',%a*,-% !#%5&,*a0 Fo&'a )a&'a*5$2,*a0 ps#%2a*,-%0 (os,),*a*,-%0 ($&a*,-% (# 2&a2a',#%2o.
23
!NQLISIS DE RESULT!DOS La posoo!"a s,&9# pa&a po(#& p&opo&*,o%a& (,)#%2#s (os,s (# '#(,*a'#%2os s#!/% # p#so0 #(a(0 1 o&!a%,s'o (# pa*,#%2#0 #s ,'po&2a%2# 1a +$# s# 3a*# $% ap&o4,'a(o (# a*$#&(o a as ps#%2a*,o%#s a%6a(as #% # '#&*a(o (# os '#(,*a'#%2os0 1a +$# %o s# p$#(# 2o'a& a (os,s #4a*2a (# os **$os poso-!,*os0 1a +$# s# %#*#s,2a&"a% a,6a& )&'a*os #sp#*"),*os pa&a *a(a p#&so%a. :F,!$#&oa0 ;<<<=. Po& #s2a &a6-%0 #s ,'po&2a%2# +$# os ##'#%2os +$# ,%9o$*&a% a a (os,),*a*,-% :D#%o',%a*,-% (,s2,%2,9a0 (#%o',%a*,-% !#%5&,*a0 )o&'a )a&'a*5$2,*a0 ps#%2a*,-%0 (os,),*a*,-%0 ($&a*,-% (# 2&a2a',#%2o= #% $%a *#2a '5(,*a #s25% ps#%2#s 1 +$#(#% s$'a'#%2# *a&os. Co'o s# 9# #% as *#2as ,sa(as0 #% a *#2a (# ,%s2,2$*,-% p/7,*a *a&a'#%2# #%*o%2&a'os #s2os ##'#%2os0 a (#%o',%a*,-% (,s2,%2,9a 1 !#%5&,*a0 as" *o'o )o&'a 1 ps#%2a*,-% )a&'a*5$2,*a 1 a (os,),*a*,-%. E% *a'7,o0 #% a *#2a (# $% '5(,*o p&,9a(o0 # '5(,*o ps*&,p2o& %o *$7 os (a2os 7s,*os o7,!a2o&,os0 1a +$# soo '#%*,o%a a (o',%a*,-% (,s2,%2,9a0 #% a!$%os *asos a )o&'a )a&'a*5$2,*a 1 a (os,),*a*,-%. Po& #s2a &a6-% # pa*,#%2# (#7# po%#& #sp#*,a a2#%*,-% #% a (os,s0 as" *o'o #% a )o&'a )a&'a*5$2,*a +$# s# # #s25 ps*&,7,#%(o0 pa&a #9,2a& $%a (os,s #&&-%#a +$# 2#%!a $% #)#*2o s$72#&ap5$2,*o o $%a (os,s +$# p$#(a 2#%#& $% #)#*2o 2-4,*o # ,%*$so #2a. E% *$a%2o a os (#'s ##'#%2os0 a'7as *#2as *$'p#% *o% os +$#&,',#%2os (# os (a2os (# '5(,*o :%o'7 2"2$o0 *5($a=0 os (a2os (# pa*,#%2#0 (,**,o%#s pa&2,*$as 1 ),&'a. A!$%os (# os )a*2os +$# s# (#7#% *o%s,(#&a& s, a 'o%o!&a)"a '5(,*a s-o ,%(,*a a (os,),*a*,-% pa&a %,os o a($2os0 so% # p#so (# pa*,#%2#0 as" *o'o a!$%as *o%(,*,o%#s '5(,*as0 *o'o a#&!,as0 +$# p$#(a% s#& $% p&o7#'a s, # '5(,*o %o as *o%o*# o as pasa po& a2o. C$a%(o $% '#(,*a'#%2o ,%(,*a as (os,s #% $%,(a(#s ,%2#&%a*,o%a#s # pa*,#%2# (#7# *o%s,(#&a& +$# # '5(,*o 3a1a 3#*3o $% *o&*2o **$o poso-!,*o0 *o% # ),% (# +$# a *a%2,(a( s#a *o&*2a pa&a 5s2#. Co'o )$2$&os L,*#%*,a(os #% B,o+$"',*a D,a!%-s2,*a a!$%as (# as *o'#%(a*,o%#s +$# 3a&"a'os pa&a 2#%#& $% 2&a2a',#%2o )a&'a*o-!,*o ,(-%#o so% ^ Es2a& ,%)o&'a(o (# #)#*2o (# *a(a $%o (# os )&'a*os. ^ Co%o*#& $% po*o so7 a 2o4,*,(a( (# os )&'a*os. ^ R#9,sa& +$# a (os,s ps*&,2a s#a *o3#%2# *o% a 'o%o!&a)"a '5(,*a.
24
CONCLUSIONES A 2&a95s (# #s2a s#s,-% 3#'os 2#%,(o $% p&,'#& a*#&*a',#%2o *o% # #%!$a8# )a&'a*o-!,*o 7s,*o pa&a ,%,*,a&%os #% a 'a2#&,a0 a (,)#%*,a #%2 a!$%os 25&',%os 1 s$ ,'po&2a%*,a0 1 s# a(+$,&,- #4p#&,#%*,a #% a so$*,-% (# p&o7#'as poso-!,*os. Ta'7,5% ,(#%2,),*a'os as pa&2#s (# $%a *#2a '5(,*a0 1 s# #9,(#%*,a&o% as (,)#%*,as #%2 $%a p/7,*a 1 $%a p&,9a(a0 as" ',s'o s# 9,o a ,'po&2a%*,a (# os **$os poso-!,*os #% a 9,(a a 1 s$s pos,7#s a*a%*#s.
!NEOS METORMIN! BIU!NID!S SOL!S DOSIS # VÍ! DE !DMINISTR!CIÓN: O&a. D)&: P-%- -*+$- '$ 500 ,: La posoo!"a #s (# ; 2a7#2a (# @@ '! a ("a # ,& ,%*'#%2a%(o a (os,s !&a($a'#%2# 3as2a $% '4,'o (# Q 2a7#2as a ("a :0@@@ '!=. !RM!COCINTIC! # !RM!CODIN!MI!: -%,-)&;&-: La a7so&*,-% ,%2#s2,%a (# a '#2)o&',%a p$#(# #42#%(#&s# a(#(o& (# Q 3o&as0 a *o%*#%2&a*,-% '4,'a #% pas'a #% $%a *o%(,*,-% #s2a7# (#sp$5s (# $%a (os,s o&a s# a*a%6a #%2 os ? a ',%$2os *o% $% p&o'#(,o (# @ _ . ',%$2os 1 9a (# ? a !'0 a 9,(a '#(,a pas'2,*a #s (# ;.? a ?.Q 3o&as *o% $% p&o'#(,o (# ;. _ @.Q 3o&as. La $%,-% a p&o2#"%as pas'2,*as #s p&*2,*a'#%2# %$a0 s$ 7,o(,spo%,7,,(a( a (os,s 2#&ap5$2,*as a*a%6a (# @ a Q@.
M$-*)+&,): S# 7,o2&a%s)o&'a '$1 po*o s$ '#2a7o,2o p&,%*,pa #s # 3,(&o4,'#2,7,!$a%,(a :3,(&o4,a*,-%= 1 #s2o s$*#(# #% 3"!a(o0 a %,9# ',*&oso'a. E+&,&-& ) $%$&: P&,%*,pa'#%2# po& os &,o%#s :<@=0 a #,',%a*,-% (# 5s2# )&'a*o #% s$8#2os sa%os 1 pa*,#%2#s (,a752,*os *o% )$%*,-% %a %o&'a #s a(#(o& (# 9#*#s a #,',%a*,-% (# a *a2,%,%a0 o *$a s$!,# +$# a a*2,9a s#**,-% 2$7$a& #s $% '#*a%,s'o ,'po&2a%2# (# #,',%a*,-%. Es2# )&'a*o 2a'7,5% s# #,',%a po& as !%($as sa,9a#s. -%,-)'&-,&-: 25
M$-&,) '$ -&: La '#2)o&',%a a$'#%2a s,!%,),*a2,9a'#%2# a ,%*o&po&a*,-% (# !$*osa a "p,(os 1 '#8o&a a #),*a*,a (# a $2,,6a*,-% (# !$*osa. A 2&a95s (# po2#%*,a& as a**,o%#s (# a ,%s$,%a #%(-!#%a a$'#%2a a s"%2#s,s (# !$*-!#%o %a 3#p2,*o. R#($*# # p&o*#so *o&po&a #% pa*,#%2#s o7#sos0 p#&o %o 'o(,),*a # (# pa*,#%2#s (#!a(os. D,s',%$1# a 3,p#&!$*#',a posp&a%(,a po& a$'#%2a& a *ap2$&a (# !$*osa po& # '/s*$o #s+$#52,*o 1 po& os a(,po*,2os0 #s2o pos,7#'#%2# (,s',%$1# # ap#2,2o 1 a1$(a a ($*,& # p#so #% os pa*,#%2#s (,a752,*os o7#sos. D,s',%$1# 2&,!,*5&,(os0 *o#s2#&o 2o2a0 (,s',%$1# LDL 1 %o ,%*'#%2a as HDL. D,s',%$1# a !$*osa 1 a ,%s$,%a pas'2,*a #% a1$%o0 '#8o&a a 2o#&a%*,a (# a !$*osa0 (,s',%$1# os %,9##s pas'2,*os (# "p,(os ,%(#p#%(,#%2#'#%2# (# *a'7,os #% # p#so *o&po&a0 ,%*'#%2a a *ap2$&a (# !$*osa #% pa*,#%2#s o7#sos 1 (,s',%$1# ,!#&a'#%2# o %o 'o(,),*a 5s2a #% pa*,#%2#s (,a752,*os (#!a(os. D,s',%$1# os %,9##s pas'2,*os (# !$*osa # ,%s$,%a0 a$'#%2a a $%,-% (# ,%s$,%a a s$ *#p2o& :#% #&,2&o*,2os 1 #% a(,po*,2os=. Es2# #)#*2o )$# apa%2# (#sp$5s (# ? 3o&as0 *o% $%a ($&a*,-% (# 's (# ? 3o&as. La M#2)o&',%a ,%*'#%2a a 9#o*,(a( 7asa (# 2&a%spo&2# (# a !$*osa0 pos,7#'#%2# a 2&a95s (# ,%*'#%2a& a s#%s,7,,(a( (# 2&a%spo&2# a a !$*osa. I%*'#%2a a a*2,9,(a( ),7&,%o"2,*a. Es2# #)#*2o #s p&o($*,(o po& $%a (,s',%$*,-% #% os %,9##s pas'2,*os (# a*2,9a(o& pas',%-!#%o ,%3,7,(o&; :PAI;=. E4,s2# #9,(#%*,a +$# s#aa +$# a a**,-% #%2 ),7&,%-,s,s (#p&,',(a 1 #%)#&'#(a( 9as*$a& #s (#7,(a a %,9##s a2os :PAI;= 1 #4,s2#% &a6o%#s pa&a *#& +$# a (,s',%$*,-% (# PAI; p$#(# s#& 7#%5),*a. A #s2# sp#*2o #s %#*#sa&,o a,6a& #s2$(,os pa&a #s2a7#*#& #s2a a*,-%.
ORM! !RM!CUTIC! # ORMUL!CIÓN C-'- TABLETA )&$$: Co&3,(&a2o (# M#2)o&',%a.................... @@0 @ '! 1 ;.@ ! E4*,p,#%2# *.7.p. ; 2a7#2a
INDIC!CIONES TER!PUTIC!S: D,a7#2#s '#,2$s #s2a7# (# a($2o0 #sp#*,a'#%2# (# o7#so0 )aas p&,'a&,as 1 s#*$%(a&,as a o2&os 3,po!$*#',a%2#s o&a#s0 (,a752,*os #% 2&a2a',#%2o *o% s$)o%,$as *o% 2#%(#%*,a a a$'#%2o (# p#so.
26
INTER!CCIONES MEDIC!MENTOS!S # DE OTRO NERO: La '#2)o&',%a po2#%*,a,6a # #)#*2o (# os a%2,*oa!$a%2#s 1 (# os ),7&,%o"2,*os0 ,%3,7# a a7so&*,-% (# a 9,2a',%a B ;?0 #% *asos a,sa(os. La '#2)o&',%a po& s" soa %o *a$sa 3,po!$*#',a. S,% #'7a&!o0 s# (#7# ps2a& a2#%*,-% a a pos,7,,(a( (# s$)&,& 3,po!$*#',a *$a%(o s# a(',%,s2&a *o%8$%2a'#%2# *o% o2&os a!#%2#s 3,po!$*#',a%2#s. La *o&p&o'a*,%a0 *o&2,*os2#&o,(#s0 (,$&52,*os0 3o&'o%as 2,&o,(#as0 s,'pa2,*o','52,*os 1 a%2,*o%*#p2,9os o&a#s +$# p$#(#% ($*,& # #)#*2o ($*2o& (# a !$*osa (# a '#2)o&',%a '#(,a%2# a a2#&a*,-% (# a 2o#&a%*,a a a !$*osa. Los a%2,,%)a'a2o&,os %o #s2#&o,(#os0 # *,(o a*#2,sa,*",*o o a *,'#2,(,%a p$#(#% ($*,& a #4**,-% %a (# '#2)o&',%a 1 po& o 2a%2o a$'#%2a& # &,#s!o (# a*,(os,s *2,*a. :PLM0 ?@;=
!MPICILIN! !MPICILIN!S DE !MPLIO ESPECTRO OR!LES DOSIS # VÍ! DE !DMINISTR!CIÓN: O&a. !'+): ?@ a @@ '! *a(a Q 3o&as. E% ,%)#**,o%#s !&a9#s0 s# a(',%,s2&a% 3as2a Q ! #% ? 3o&as. ))%%$-: . ! *o'o (os,s /%,*a 1 ; ! (# p&o7#%#*,(. ))%%$-: @@ '! *a(a ;? 3o&as *o% (os,s /%,*as. M$&&& *-$%&--G $(&$,&-: ;@ a ?@@ '!!("a #% (os,s (,9,(,(as po& ,!$a *a(a o 3o&as. N&): Has2a ?@ ! (# p#so *o&po&a0 ;?. a ? '!! *a(a Q 3o&as. E% ,%)#**,o%#s !&a9#s s# a$'#%2a 3as2a ?@@ '!! (# p#so("a0 (,9,(,(os #% *$a2&o (os,s ,!$a#s. !'+): ;? 2a7#2as (# ; ! *a(a Q $ 3o&as. !RM!COCINTIC! # !RM!CODIN!MI!: S$ #sp#*2&o a%2,7a*2#&,a%o #s 's a'p,o +$# # (# as p#%,*,,%as %a2$&a#s0 #s (#s2&$,(a po& a `a*2a'asa p&o($*,(a po& !&a'pos,2,9os 1 !&a'%#!a2,9os 10 po& o 2a%2o0 #s ,%#)#*2,9a #% as ,%)#**,o%#s p&o($*,(as po& #s2a),o*o*os. Ca7# '#%*,o%a& +$# in vivo #s 9a&,a7#'#%2# #)#*2,9a *o%2&a H. influenzae, E. coli, P. mirabilis, N. gonorrhoeae, S. pneumoniae, S. pyogenes. N. meningitidis 1 S. typhi. T,#%# #)#*2o
27
-%,-)'&-,&-: La a'p,*,,%a ,%3,7# a s"%2#s,s (# a pa( *#$a& (# 7a*2#&,as s$s*#p2,7#s. E #9#%2o 2#&',%a (# a s"%2#s,s (# a pa( *#$a& #s a )o&'a*,-% (# $%,o%#s *&$6a(as (# $%,(a(#s (# p#p2,(o!,*a%o '#(,a%2# $%a a**,-% (# 2&a%sp#p2,(a*,-%. Las p#%,*,,%as s# $%#% a s,2,o a*2,9o (# a #%6,'a 2&a%sp#p2,(asa 1 p ,#%#% a )o&'a*,-% (# as $%,o%#s *&$6a(as 10 po& o 2a%2o0 ,%3,7#% a )o&'a*,-% (# a pa( *#$a&. As,',s'o0 s# 3a po&2a(o +$# as p#%,*,,%as a*2,9a% $% s,s2#'a a$2o"2,*o #%(-!#%o +$# ,%,*,a a ,s,s *#$a& 1 a '$#&2# #% a!$%as 7a*2#&,as. La a'p,*,,%a #s s,',a& a a 7#%*, p#%,*,,%a #% s$ a**,-% 7a*2#&,*,(a *o%2&a o&!a%,s'os s$s*#p2,7#s0 #sp#*,a'#%2# ($&a%2# # #s2a(,o (# '$2,p,*a*,-%. Es po& #s2a &a6-% +$# a a'p,*,,%a %o (#7# a(',%,s2&a&s# *o%8$%2a'#%2# *o% a!#%2#s 7a*2#&,os22,*os *o'o # *o&a%)#%,*o0 as 2#2&a*,*,%as0 a #&,2&o',*,%a o as s$)o%a',(as0 1a +$# #s2os a%2,7,-2,*os ,%3,7#% a a**,-% 7a*2#&,*,(a (# a a'p,*,,%a. -%,-)&;&-: La a'p,*,,%a ps#%2a $%a )a&'a*o*,%52,*a ,%#a. Es #s2a7# #% *,(o0 po& o +$# s# a7so&7# '#8o& (# 2&a*2o !as2&o,%2#s2,%a +$# a 7#%*, p#%,*,,%a o p#%,*,,%a G. S,% #'7a&!o0 pos## $%a 7,o(,spo%,7,,(a( (# @ #% a1$%as. Los a,'#%2os a&(a% 1 ($*#% a a7so&*,-%. La *o%*#%2&a*,-% pas'2,*a '4,'a (#sp$5s (# $%a a(',%,s2&a*,-% (# @@ '! #% *ps$as s# a*a%6a #% ; a ? 3o&as0 *o% $%a C'4. (# ''. S# $%# #% ; a ?@ a as p&o2#"%as pas'2,*as. S$ 9o$'#% apa%2# (# (,s2&,7$*,-% 9a&"a #%2 ;<. a ? ,2&os. S# a*a%6a% *o%*#%2&a*,o%#s ##9a(as #% a 7,,s0 +$# 9a&"a% (# @. a Q. '' #% $% p#&,o(o (# ;? 3o&as (#sp$5s (# $%a a(',%,s2&a*,-% o&a (# @@ '!. E% 3$#so 2a'7,5% s# a*a%6a% *o%*#%2&a*,o%#s ##9a(as0 as" *o'o #% o&,%a 1 "+$,(o p&os22,*o. No a2&a9,#sa #% *o%*#%2&a*,o%#s 2#&ap5$2,*as a s,s2#'a %#&9,oso *#%2&a0 #4*#p2o *$a%(o #4,s2# ,%)a'a*,-% (# '#%,%!#s. La a'p,*,,%a s# #,',%a p&,%*,pa'#%2# po& a o&,%a 1 #% '#%o& p&opo&*,-% po& as 3#*#s0 s,% 7,o2&as)o&'a*,-%0 1a +$# s-o ;@ (# )&'a*o #s '#2a7o,6a(o. La #,',%a*,-% %a #s (# #%2 @ a 0 p&,%*,pa'#%2# po& s#**,-% 2$7$a&. Ta'7,5% s# #,',%a po& 9"a 7,,a& #% *a%2,(a(#s '#%os. S# 3a o7s#&9a(o +$# 2a'7,5% s# #,',%a a 2&a95s (# a #*3#0 a$%+$# as *o%*#%2&a*,o%#s pas'2,*as #% a #*3# 'a2#&%a so% 7a8as. Ps#%2a $%a 9,(a '#(,a (# #,',%a*,-% (# ; a ? 3o&as. S# 3a o7s#&9a(o +$# a *o%*#%2&a*,-% 2,s$a& (# a a'p,*,,%a s# #%*$#%2&a #%2 a ;@ 9#*#s po& a&&,7a (# a *o%*#%2&a*,-% '"%,'a ,%3,7,2o&,a :MIC0 po& s$s s,!as #% ,%!5s= (# *#pas s#%s,7#s +$# #s (# ;. !. E% pa*,#%2#s 9o$%2a&,os '#4,*a%os0 a a(',%,s2&a*,-% (# a'p,*,,%a *ps$as a $%a (os,s (# ; ! o&,!,%a $%a C'4. (# . !' #% $% T'4. (# ?.@< 3o&as. Es2os pa&'#2&os )a&'a*o*,%52,*os so% s#'#8a%2#s 1 7,o#+$,9a#%2#s *o% a a'p,*,,%a #% *ps$as (# )#%*,a.
ORM! !RM!CUTIC! # ORMUL!CIÓN:
28
C-'- CÁPSULA )&$$: A'p,*,,%a 2&,3,(&a2a(a #+$,9a#%2# a @@ '! (# a'p,*,,%a E4*,p,#%2#0 *.7.p. ; *ps$a.
C-'- CÁPSULA )&$$: A'p,*,,%a 2&,3,(&a2a(a #+$,9a#%2# a ?@ '! (# a'p,*,,%a E4*,p,#%2#0 *.7.p. ; *ps$a.
C-'- 5 ,+ '$ SUSPENSIÓN )&$$: A'p,*,,%a 2&,3,(&a2a(a #+$,9a#%2# a ?@ '! (# a'p,*,,%a 7as# V#3"*$o0 *.7.p. '.
C-'- TABLETA )&$$: A'p,*,,%a a%3,(&a @@ '! 1 ; ! E4*,p,#%2#0 *.7.p. ; 2a7#2a.
INDIC!CIONES TER!PUTIC!S: I%)#**,o%#s (# apa&a2o sp,&a2o&,o0 (# apa&a2o (,!#s2,9o0 (# apa&a2o $&,%a&,o0 ,%)#**,o%#s (# a p,#0 2#8,(os 7a%(os0 o(o%2o-!,*as0 s#p2,*#',as0 '#%,%!,2,s0 #%(o*a&(,2,s 7a*2#&,a%a # ,%)#**,o%#s o*as,o%a(as po& !5&'#%#s s#%s,7#s. I%)#**,o%#s !&a9#s po& ',*&oo&!a%,s'os s$s*#p2,7#s0 #% #sp#*,a *#pas (# Haemophilus, Salmonella, Escherichia, Shigella, Proteus 1 Neisseria.
INTER!CCIONES MEDIC!MENTOS!S # DE OTRO NERO: E *ao"% (,s',%$1# s$ a7so&*,-% 1 *o% #o a 7,o(,spo%,7,,(a( (# a a'p,*,,%a. La a(',%,s2&a*,-% (# a'p,*,,%a p$#(# (,s',%$,& #% )o&'a pasa8#&a os %,9##s pas'2,*os (# #s2&-!#%os 1 p&o!#s2!#%os0 po& o 2a%2o0 p$#(# ($*,& a p&o2#**,-% *o%2&a # #'7a&a6o #% pa*,#%2#s +$# #s2% 7a8o 2&a2a',#%2os a%o9$a2o&,os. La a(',%,s2&a*,-% s,'$2%#a (# aop$&,%o 1 a a'p,*,,%a ,%*'#%2a s$s2a%*,a'#%2# a ,%*,(#%*,a (# #4a%2#'as #% pa*,#%2#s +$# *,7#% a'7os 29